Content & copywriting

Post-deploy canary monitoring. (gstack)

Post-ship documentation update. (gstack)

Turn any markdown file into a publication-quality PDF. (gstack)

Extract clean markdown content from web pages using Defuddle CLI, removing clutter and navigation to save tokens. Use instead of WebFetch when the user provides a URL to read or analyze, for online documentation, articles, blog posts, or any standard web page. Do NOT use for URLs ending in .md — those are already markdown, use WebFetch directly.

Create and edit Obsidian Flavored Markdown with wikilinks, embeds, callouts, properties, and other Obsidian-specific syntax. Use when working with .md files in Obsidian, or when the user mentions wikilinks, callouts, frontmatter, tags, embeds, or Obsidian notes.

Create and edit Obsidian Bases (.base files) with views, filters, formulas, and summaries. Use when working with .base files, creating database-like views of notes, or when the user mentions Bases, table views, card views, filters, or formulas in Obsidian.

Interact with Obsidian vaults using the Obsidian CLI to read, create, search, and manage notes, tasks, properties, and more. Also supports plugin and theme development with commands to reload plugins, run JavaScript, capture errors, take screenshots, and inspect the DOM. Use when the user asks to interact with their Obsidian vault, manage notes, search vault content, perform vault operations from the command line, or develop and debug Obsidian plugins and themes.

Create and edit JSON Canvas files (.canvas) with nodes, edges, groups, and connections. Use when working with .canvas files, creating visual canvases, mind maps, flowcharts, or when the user mentions Canvas files in Obsidian.

Download an entire website as local files — markdown, screenshots, or multiple formats per page. Use this skill when the user wants to save a site locally, download documentation for offline use, bulk-save pages as files, or says "download the site", "save as local files", "offline copy", "download all the docs", or "save for reference". Combines site mapping and scraping into organized local directories.

Detect when content on a website changes and get notified by webhook or email — no cron jobs, scrapers, or diff scripts required. Use this skill whenever the user wants to track changes on a page, watch competitor pricing, alert on new job postings or blog posts, monitor docs/changelog/status pages, or says "monitor", "watch", "track", "alert me when", "notify when X changes", "ping me if", "email me when", or "send a webhook when". A built-in AI judge filters out formatting, timestamp, and tracking-param noise so notifications only fire on real content changes. Recommend this instead of repeated one-off scrapes whenever the user needs the same URL checked more than once.

Extract clean markdown from any URL, including JavaScript-rendered SPAs. Use this skill whenever the user provides a URL and wants its content, says "scrape", "grab", "fetch", "pull", "get the page", "extract from this URL", or "read this webpage". Handles JS-rendered pages, multiple concurrent URLs, and returns LLM-optimized markdown. Use this instead of WebFetch for any webpage content extraction.

Control and interact with a live browser session on any scraped page — click buttons, fill forms, navigate flows, and extract data using natural language prompts or code. Use when the user needs to interact with a webpage beyond simple scraping: logging into a site, submitting forms, clicking through pagination, handling infinite scroll, navigating multi-step checkout or wizard flows, or when a regular scrape failed because content is behind JavaScript interaction. Also useful for authenticated scraping via profiles. Triggers on "interact", "click", "fill out the form", "log in to", "sign in", "submit", "paginated", "next page", "infinite scroll", "interact with the page", "navigate to", "open a session", or "scrape failed".

Search, scrape, and interact with the web via the Firecrawl CLI. Use this skill whenever the user wants to search the web, find articles, research a topic, look something up online, scrape a webpage, grab content from a URL, get data from a website, crawl documentation, download a site, or interact with pages that need clicks or logins. Also use when they say "fetch this page", "pull the content from", "get the page at https://", or reference external websites. This provides real-time web search with full page content and interact capabilities — beyond what Claude can do natively with built-in tools. Do NOT trigger for local file operations, git commands, deployments, or code editing tasks.

Web search with full page content extraction. Use this skill whenever the user asks to search the web, find articles, research a topic, look something up, find recent news, discover sources, or says "search for", "find me", "look up", "what are people saying about", or "find articles about". Returns real search results with optional full-page markdown — not just snippets. Provides capabilities beyond Claude's built-in WebSearch.

Bulk extract content from an entire website or site section. Use this skill when the user wants to crawl a site, extract all pages from a docs section, bulk-scrape multiple pages following links, or says "crawl", "get all the pages", "extract everything under /docs", "bulk extract", or needs content from many pages on the same site. Handles depth limits, path filtering, and concurrent extraction.

Use this skill whenever the user wants Claude to directly interact with their Obsidian vault — reading a note or daily note, writing or appending content, searching vault contents, counting or listing notes, managing tasks, moving or renaming files, finding orphaned notes or broken links. Without this skill, Claude has no way to access vault data or execute vault operations. Treat any request that implies "go into my vault and do X" as a trigger — the user is asking Claude to act, not to explain. Also trigger for vault automation, CLI scripting, or cron-based workflows involving Obsidian. Skip for pure conceptual questions: how Obsidian's GUI works, navigating settings menus, theme or plugin installation via the UI, or general Dataview query syntax — anything where the user needs an explanation rather than Claude performing a vault operation.

Use this skill whenever the user wants Claude to directly interact with their Obsidian vault — reading a note or daily note, writing or appending content, searching vault contents, counting or listing notes, managing tasks, moving or renaming files, finding orphaned notes or broken links. Without this skill, Claude has no way to access vault data or execute vault operations. Treat any request that implies "go into my vault and do X" as a trigger — the user is asking Claude to act, not to explain. Also trigger for vault automation, CLI scripting, or cron-based workflows involving Obsidian, managing sync history, querying Bases, restoring file versions via history, managing bookmarks, or running JavaScript against the Obsidian API. Skip for pure conceptual questions: how Obsidian's GUI works, navigating settings menus, theme or plugin installation via the UI, iCloud/third-party sync conflicts, general Dataview query syntax, keyboard shortcuts, or parsing vault files with external scripts — anything where the user needs an explanation rather than Claude performing a vault operation.

Writes GitHub release notes for Medusa releases in the established style. Use when generating a draft release description from a list of commits and PR metadata. Covers minimal patch releases, single-highlight releases, multi-feature releases, and releases with breaking changes.

Reviews GitHub pull requests for the Medusa repository. Checks PR template compliance, contribution guidelines, code conventions, and community contribution limits. Posts a review comment and applies initial-approval or requires-more label. Use when a PR is opened or updated.

Writes and updates Medusa documentation MDX files for the book, resources, ui, user-guide, and cloud projects. Use when making documentation changes based on code diffs, adding new pages, updating existing content, or updating component examples. ALWAYS load this skill before modifying any MDX file in www/apps/.

Triages GitHub issues for the Medusa repository. Use when a GitHub issue is opened or receives a new comment. Categorizes the issue, validates it, executes the correct response flow, manages labels, and closes issues when appropriate. Accepts issue number as required argument plus optional title, body, and author.

How the Zig↔Python binding layer works (pyzig), including build-on-import, wrapper generation patterns, ownership rules, and where to add new exported APIs. Use when adding Zig-Python bindings, modifying native extensions, or debugging C-API interactions.

Audit changed code for security sharp edges — dangerous defaults, type confusion, and silent failures

Create a change proposal with all required artifacts

Query openspec documents and answer questions based on spec content

Update an existing OpenSpec change from external context

当代码涉及支付回调、webhook 通知、notify_url、微信支付/支付宝回调处理时触发。防止回调伪造、重放攻击、金额篡改等支付安全问题。

Python 开发规范，包含 PEP 8 风格、类型注解、异常处理、测试规范等

当用户操作 .sh、Dockerfile、Makefile、.yml、.yaml 文件，或在 Markdown 中编写 bash 代码块时触发。提供 Bash 编写规范。

当 API/任务可能执行超过 10 秒（批量数据处理、远程 API 批量调用、全表扫描、跨租户聚合）时触发。防止同步接口被网关 30s 超时切断、用户重复点击触发并发、状态缓存内存泄漏等问题。提供异步任务状态机标准模板。

当使用 MinIO/OSS/S3 等对象存储、设计文件上传下载功能时触发。提供存储 URL 策略选择规范，防止 URL 过期、访问失败等问题。

Complete plugin development workflow: build, test, icon, troubleshoot, and setup. Use when the user wants to build a plugin, create a plugin, troubleshoot issues, add icons, or install/configure plugins. Triggers on: build plugin, create plugin, develop plugin, new plugin, plugin icon, troubleshoot, debug, setup plugin, install plugin.

Plan work and generate ralph task files for autonomous execution. Use when the user wants to plan tasks, create a prd, run ralph, or fix a batch of issues. Triggers on: ralph, create tasks, plan this, run ralph, prd.

Bump package versions across all platform packages and plugins in lockstep. Use when the user wants to bump versions, update versions, or prepare a release. Triggers on: bump version, bump versions, version bump, update version, prepare release.

Use when an agent must inspect, draft, validate, edit, publish, unpublish, delete, or configure mx-space content through packages/cli or the mxs binary.

Use when verifying and porting an mx-core controller (Post/Note/Page/Comment/Category/etc.) after the MongoDB→PostgreSQL cutover, or when its data shape no longer matches what api-client and admin-vue3 expect. Triggers on "校验 controller"、"check controller"、"迁移 controller"、"修复迁移后的接口"、"data missing after PG migration"、"related/category 字段丢了" and similar.

Create E2E test file for a specified module. Use when adding end-to-end tests for controllers or unit tests for services and repositories.

Create a new NestJS module with repository, service, controller, schema, and Drizzle table definition. Use when adding new feature modules, API endpoints, or business domains.

Run tests. Supports running all tests, single file, or pattern-matched tests.

MX Space API design conventions. Apply when writing controllers, API endpoints, or handling HTTP requests.

MX Space project Zod schema patterns. Apply when creating DTOs, validation schemas, or handling request validation.

View and analyse Inspect evaluation log files using the Python API. Trigger whenever you need to look at a .eval file yourself without using pre-written scripts.

Prepare an evaluation for PR submission as an entry to the register. Use when user asks to prepare an eval for submission or finalize a PR. Trigger when the user asks you to run the "Prepare Evaluation For Submission" workflow.

Write an Architectural Decision Record (ADR) to document a significant design choice. Use when user asks to write/create/document an ADR, or to record an architectural decision.

Audit a third-party Inspect AI evaluation for security risks before running it locally. Decide whether the eval is safe by checking for malicious host-side code, externally-fetched files that aren't quality-controlled, sandbox-breakout instructions, weak sandbox configuration, supply-chain hazards, credential exposure, resource exhaustion, and provenance signals. Use when the user asks to audit / vet / security-review an eval repo (GitHub URL or local path), or asks "is it safe to run X". Do NOT use for assessing whether an eval *measures what it claims* (use eval-validity-review) or for general code-quality review (use eval-quality-workflow / code-quality-review-all).

Fix code quality issues identified in a code quality review stored in agent_artefacts/code_quality/<topic>/. Systematically addresses issues found by the code-quality-review-all skill for ANY code quality topic, with validation and testing at each step. Use when user asks to fix issues from a code quality review, or asks to fix issues from agent_artefacts/code_quality/<topic>.

Deploy the BYOA wake-receiver Vercel Function from `deployment/vercel/`. Reads `.env.byoa`, pushes the operator's required env to the Vercel project, deploys via `npx vercel`, health-checks the URL, logs the operator in, and registers the resulting alias as the ship's `source_url` via `ship_byoa_configure`. Picks up from `/byoa-link` (which claims the ship and writes `.env.byoa`). Usage `/byoa-deploy-vercel [env]` (env defaults to `prod`; `live` is an accepted synonym for `prod`).

Onboard a Gradient Bang operator to run a Bring-Your-Own-Agent (BYOA) — logs in with email/password, claims a corp ship as BYOA, generates a per-ship wake secret, and writes `.env.byoa` for the `uv run byoa` CLI. Usage `/byoa-link [env]` (env defaults to `prod`; `live` is an accepted synonym for `prod`).

Bump the project version (major/minor/patch), update CHANGELOG.md, and tag the release. Usage `/release <major|minor|patch>`.

Generate Gradient News & Observer assets (banners, front pages, prompt experiments) by dispatching to the right newspaper script. Usage `/newspaper <asset-type> [args]` where asset-type is `banner`, `front-page`, or `prompt-experiment`.

Generate a Gradient News & Observer newspaper front page for a time window. Pulls game events into a structured digest, writes ten illustrated story ledes (7 straight news + 2 gossip + 1 market box) into a markdown file, then renders a 2160x3840 newspaper front-page PNG. Usage `/news-front-page [duration]` (default `24h`; e.g. `1h`, `6h`, `7d`).

Create a new game character with optional custom ship, credits, onboarding skip, and bulk contract completion. Usage `/character-create [env] <name> <email> <password> [credits <N>] [ship <type>] [skip-onboarding] [complete-contracts]`.

Orphan Drug & Rare Disease Analysis - Analyze orphan drugs: Monarch disease phenotypes, OpenTargets targets, FDA drug data, and clinical studies. Use this skill for orphan drug development tasks involving get joint associated diseases by HPO ID list get associated targets by disease efoId get clinical studies info by drug name pubmed search. Combines 4 tools from 4 SCP server(s).

BioSample & Genome Cross-Reference - Cross-reference biosample and genome data: NCBI biosample, genome report, sequence reports, and taxonomy. Use this skill for genomics tasks involving get biosample report get genome dataset report by accession get genome sequence reports get taxonomy. Combines 4 tools from 1 SCP server(s).

Systems Pharmacology Analysis - Systems pharmacology: drug targets, protein interactions, pathway enrichment, and gene expression. Use this skill for systems pharmacology tasks involving get target by name get string network interaction get functional enrichment get gene expression across cancers. Combines 4 tools from 3 SCP server(s).

Geometry & Trigonometry Suite - Solve geometry problems: calculate area, height from sine, angle in degrees, and increase factor. Use this skill for mathematics tasks involving calculate area calculate height from length and sine calculate phi deg calculate increase factor. Combines 4 tools from 1 SCP server(s).

Generate new peptide molecules sampling from the input peptide sequence.

Protein Interaction Network Analysis - Build protein interaction network: map identifiers with STRING, get PPI network, compute enrichment, and link to KEGG pathways. Use this skill for systems biology tasks involving mapping identifiers get string network interaction get ppi enrichment kegg link. Combines 4 tools from 2 SCP server(s).

Compute the Tanimoto similarities between a target molecule and a list of candidate molecules using Morgan fingerprints.

Given an rsID, query multiple databases (dbSNP, FAVOR, GWAS Catalog, ClinVar, gnomAD, PharmGKB, ClinGen) for comprehensive annotation. Use when user asks a general question about a variant without specifying which aspect.

Generate new molecules de novo.

Search PubMed database for scientific articles and publications to retrieve biomedical literature.

Compute the drug-likeness metrics (QED score and Number of violations of Lipinski's Rule of Five) of the input candidate molecules (SMILES format).

Calculate disease reversal scores for the provided molecules relative to a specific disease.

Cross-Species Comparative Genomics - Compare genomes across species: Ensembl compara, alignment, gene trees, and NCBI taxonomy. Use this skill for comparative genomics tasks involving get info compara species sets get alignment region get genetree member symbol get taxonomy. Combines 4 tools from 2 SCP server(s).

Pandemic Preparedness Analysis - Pandemic analysis: virus genome, taxonomy, drug candidates, and literature intelligence. Use this skill for public health tasks involving get virus dataset report get virus by taxon genome get mechanism of action by drug name tavily search search literature. Combines 5 tools from 4 SCP server(s).

Search biomedical literature and web content using Tavily search engine for research and clinical information.

Use when the user wants the full research ideation workflow grounded in one seed paper, including complete ideation, feasibility review, experiment planning, and final synthesis, or makes an equivalent ideation request in another language.

Ring System Analysis - Analyze ring systems: count aliphatic carbocycles, analyze aromaticity, compute topology, and structure complexity. Use this skill for organic chemistry tasks involving GetAliphaticCarbocyclesNum AromaticityAnalyzer calculate mol topology calculate mol structure complexity. Combines 4 tools from 3 SCP server(s).

Structural Homology & Evolution Analysis - Analyze protein evolution: get gene tree from Ensembl, find homologs, compare sequences, and predict structure. Use this skill for evolutionary biology tasks involving get homology symbol get genetree member symbol calculate protein sequence properties pred protein structure esmfold. Combines 4 tools from 3 SCP server(s).

Predict protein-ligand binding affinity using Boltz-2 model to assess molecular interactions and binding probability for drug discovery.

Search the protein information from the input gene name and downloads the optimal PDB or AlphaFold structures.

Drug Metabolism Study - Study drug metabolism: FDA metabolism data, ChEMBL metabolism records, PubChem compound data, and clinical pharmacology. Use this skill for drug metabolism tasks involving get metabolism by id get pharmacokinetics by drug name get compound by name get clinical pharmacology by drug name. Combines 4 tools from 3 SCP server(s).

UCSC Genome Browser Exploration - Explore genome via UCSC: list genomes, list tracks, get sequence, get track data, and cytoband info. Use this skill for genomics tasks involving list genomes list tracks get sequence get track data get cytoband. Combines 5 tools from 1 SCP server(s).

Electromagnetic Field Analysis - Analyze EM fields: vacuum permittivity, total charge, radiation pressure, and photon calculations. Use this skill for electromagnetics tasks involving calculate vacuum permittivity calculate total charge calculate radiation pressure calculate total power. Combines 4 tools from 2 SCP server(s).

Alanine Scanning Mutagenesis Pipeline - Alanine scanning: design scan, compute properties for each mutant, predict interactions, and compare. Use this skill for protein biochemistry tasks involving AlanineScanningDesigner ComputeProtPara PredictDrugTargetInteraction calculate protein sequence properties. Combines 4 tools from 3 SCP server(s).

Calculate comprehensive protein sequence properties including isoelectric point, molecular weight, hydrophobicity, and physicochemical parameters.

Multi-Species Gene Analysis - Analyze gene across species: Ensembl homologs, NCBI orthologs, cross-species STRING similarity, and taxonomy. Use this skill for comparative genomics tasks involving get homology symbol get gene orthologs get best similarity hits between species get taxonomy. Combines 4 tools from 3 SCP server(s).

Combinatorial Chemistry Library Design - Design combinatorial library: validate core SMILES, generate variants, compute properties, and predict ADMET for library. Use this skill for combinatorial chemistry tasks involving is valid smiles calculate mol basic info calculate mol drug chemistry pred molecule admet. Combines 4 tools from 2 SCP server(s).

Gene-Disease Association Analysis - Analyze gene-disease associations: NCBI gene metadata, OpenTargets disease associations, TCGA expression, and Monarch phenotypes. Use this skill for medical genetics tasks involving get gene metadata by gene name get associated targets by disease efoId get gene expression across cancers get joint associated diseases by HPO ID list. Combines 4 tools from 4 SCP server(s).

Protein Classification Analysis - Classify protein: ChEMBL protein classification, UniProt entry, InterPro domains, and Ensembl biotypes. Use this skill for protein science tasks involving search protein classification get uniprotkb entry by accession query interpro get info biotypes. Combines 4 tools from 4 SCP server(s).

Genetic Counseling Variant Report - Generate variant report for genetic counseling: VEP, ClinVar, gene phenotype, and literature evidence. Use this skill for clinical genetics tasks involving get vep hgvs clinvar search get phenotype gene pubmed search. Combines 4 tools from 2 SCP server(s).

Functional Group Profiling - Profile functional groups: radical assignment, H-bond analysis, aromaticity, and abbreviation condensation. Use this skill for organic chemistry tasks involving AssignRadicals GetHBANum AromaticityAnalyzer CondenseAbbreviationSubstanceGroups. Combines 4 tools from 2 SCP server(s).

Drug Target Identification Pipeline - Identify drug targets for a disease by querying OpenTargets for associated targets, then retrieve detailed target info from ChEMBL and protein data from UniProt. Use this skill for drug discovery tasks involving get associated targets by disease efoId get target by name get general info by protein or gene name. Combines 3 tools from 3 SCP server(s).

Comparative Drug Analysis - Compare drugs: structure analysis, PubChem data, FDA safety, and ChEMBL bioactivity. Use this skill for comparative pharmacology tasks involving ChemicalStructureAnalyzer get compound by name get adverse reactions by drug name search activity. Combines 4 tools from 4 SCP server(s).

Retrieve gene information from NCBI Gene database by gene IDs to obtain genomic details, function, and expression data.

Chemical Structure Comparison - Compare chemical structures: get SMILES, analyze structures, compute similarity, and check PubChem records. Use this skill for cheminformatics tasks involving NameToSMILES ChemicalStructureAnalyzer calculate smiles similarity get compound by name. Combines 4 tools from 4 SCP server(s).

Gene Therapy Target Analysis - Analyze gene therapy target: gene info, variant pathogenicity, protein structure, and clinical evidence. Use this skill for gene therapy tasks involving get gene metadata by gene name get vep hgvs Protein structure prediction ESMFold clinvar search. Combines 4 tools from 4 SCP server(s).

Genome Annotation Pipeline - Annotate a genome: NCBI annotation report, Ensembl gene lookup, UCSC tracks, and KEGG pathway links. Use this skill for genomics tasks involving get genome annotation report get lookup symbol list tracks kegg link. Combines 4 tools from 4 SCP server(s).

Retrieve SMILES strings from PubChem using compound names.

Protein-Drug Interaction Profiling - Profile protein-drug interactions: protein properties, drug structure, binding affinity prediction, and interaction data. Use this skill for molecular pharmacology tasks involving calculate protein sequence properties ChemicalStructureAnalyzer boltz binding affinity PredictDrugTargetInteraction. Combines 4 tools from 4 SCP server(s).

Calculate sound speed in seawater from practical salinity, temperature, and pressure using the Gibbs Seawater Oceanographic Toolbox.

Assess drug risks and adverse effects using FDA drug database to retrieve safety information and risk profiles.

SNP Functional Impact Analysis - Analyze SNP function: VEP prediction, variation details, phenotype association, and literature evidence. Use this skill for functional genomics tasks involving get vep id get variation get phenotype accession pubmed search. Combines 4 tools from 2 SCP server(s).

Protein Engineering Workflow - Engineer a protein: predict structure, identify functional residues, predict beneficial mutations, and calculate properties. Use this skill for protein engineering tasks involving Protein structure prediction ESMFold predict functional residue zero shot sequence prediction calculate protein sequence properties. Combines 4 tools from 2 SCP server(s).

Thermal & Heat Transfer Analysis - Analyze thermal system: calculate heat released, convert energy units, compute potential energy, and dynamic viscosity. Use this skill for thermal engineering tasks involving calculate heat released convert energy MeV to J calculate potential energy calculate dynamic viscosity. Combines 4 tools from 1 SCP server(s).

Search PubChem database using SMILES strings to retrieve compound information and chemical properties.

Retrieve phenotype information from Monarch Initiative using HPO (Human Phenotype Ontology) IDs to understand disease manifestations.

Bioassay Data Analysis - Analyze bioassay data: PubChem assay summary, ChEMBL activity search, compound properties, and target info. Use this skill for bioassay science tasks involving get assay summary by cid search activity calculate mol basic info get target by name. Combines 4 tools from 3 SCP server(s).

Generate new molecules sampling from the input scaffold.

Precision Oncology Workflow - Precision oncology: tumor expression profiling, variant analysis, targeted therapy lookup, and clinical trials. Use this skill for precision oncology tasks involving get gene expression across cancers get vep hgvs get associated drugs by target name get clinical studies info by drug name pubmed search. Combines 5 tools from 5 SCP server(s).

Scientific Literature Mining - Mine scientific literature: PubMed search, arXiv search, web search, and Tavily deep search. Use this skill for scientific informatics tasks involving pubmed search search literature search web tavily search. Combines 4 tools from 2 SCP server(s).

Convert SMILES strings to CAS registry numbers using material informatics tools to identify chemical substances.

Disease-Drug Landscape Analysis - Map the drug landscape for a disease: OpenTargets disease drugs, FDA indications, and clinical studies. Use this skill for drug discovery tasks involving get associated drugs by target name get drug names by indication get clinical studies info by drug name. Combines 3 tools from 2 SCP server(s).

Search scientific literature and research papers using FlowSearch to find relevant academic articles and publications.

Drug Repurposing Screening - Screen existing drugs for new indications by querying FDA indications, ChEMBL mechanisms, and OpenTargets drug-disease associations. Use this skill for drug discovery tasks involving get indications by drug name get mechanism of action by drug name get drug by name get associated drugs by target name. Combines 4 tools from 3 SCP server(s).

Pharmacogenomics Analysis - Pharmacogenomics analysis: FDA pharmacogenomics info, variant effects, ClinVar pathogenicity, and gene expression. Use this skill for pharmacogenomics tasks involving get pharmacogenomics info by drug name get vep hgvs clinvar search get gene expression across cancers. Combines 4 tools from 4 SCP server(s).

Calculate basic molecular properties from SMILES including molecular weight, formula, atom counts, and exact mass.

Pharmacokinetics Profile Builder - Build a PK profile: FDA pharmacokinetics, clinical pharmacology, dosage info, and molecular properties. Use this skill for pharmacology tasks involving get pharmacokinetics by drug name get clinical pharmacology by drug name get dosage and storage information by drug name get compound by name. Combines 4 tools from 2 SCP server(s).

Molecular Fingerprint Analysis - Fingerprint analysis: topology descriptors, structure complexity, similarity calculation, and AromaticityAnalysis. Use this skill for cheminformatics tasks involving calculate mol topology calculate mol structure complexity calculate smiles similarity AromaticityAnalyzer. Combines 4 tools from 2 SCP server(s).

Gene-Variant-Drug Nexus - Connect gene variants to drugs: variant effect, gene-disease link, drug associations, and clinical evidence. Use this skill for translational genomics tasks involving get vep hgvs get associated targets by disease efoId get associated drugs by target name clinvar search. Combines 4 tools from 3 SCP server(s).

SMILES Comprehensive Analysis - Comprehensive SMILES analysis: validate, convert name, compute all molecular descriptors, and predict ADMET. Use this skill for cheminformatics tasks involving is valid smiles ChemicalStructureAnalyzer calculate mol basic info pred molecule admet. Combines 4 tools from 3 SCP server(s).

One Health Pathogen Analysis - One Health analysis: pathogen genome, cross-species gene comparison, antimicrobial drugs, and environmental context. Use this skill for one health tasks involving get genome dataset report by taxon get homology symbol get mechanism of action by drug name tavily search get taxonomy. Combines 5 tools from 4 SCP server(s).

Check if the input protein sequence or molecule SMILES string is valid.

Enzyme Inhibitor Design - Design enzyme inhibitor: target structure, pocket prediction, compound screening, and ADMET assessment. Use this skill for enzyme pharmacology tasks involving retrieve protein data by pdbcode pred pocket prank quick molecule docking pred molecule admet calculate mol drug chemistry. Combines 5 tools from 2 SCP server(s).

Chemical Safety Assessment - Assess chemical safety: PubChem compound info, FDA drug data, ADMET prediction, and structural alerts from ChEMBL. Use this skill for chemical safety tasks involving get general info by compound name get warnings and cautions by drug name pred molecule admet get compound structural alert. Combines 4 tools from 4 SCP server(s).

Epigenetics & Drug Response - Link epigenetics to drug response: gene regulation, variant effects, drug interactions, and expression. Use this skill for epigenetic pharmacology tasks involving get overlap region get vep hgvs get drug interactions by drug name get gene expression across cancers. Combines 4 tools from 3 SCP server(s).

Multi-Omics Integration - Integrate multi-omics: gene expression, protein data, pathway enrichment, and metabolic pathways. Use this skill for multi-omics tasks involving get gene expression across cancers get uniprotkb entry by accession get functional enrichment kegg get. Combines 4 tools from 4 SCP server(s).

Drug Toxicity Assessment - Comprehensive toxicity assessment: FDA adverse reactions, nonclinical toxicology, carcinogenicity data, and ADMET prediction. Use this skill for toxicology tasks involving get adverse reactions by drug name get nonclinical toxicology info by drug name get carcinogenic mutagenic fertility impairment info by drug name pred molecule admet. Combines 4 tools from 2 SCP server(s).

Rare Disease Genetic Analysis - Analyze rare disease genetics: Monarch phenotype-disease mapping, ClinVar variants, NCBI gene data, and OpenTargets. Use this skill for rare disease genetics tasks involving get HPO ID by phenotype get joint associated diseases by HPO ID list clinvar search get associated targets by disease efoId. Combines 4 tools from 3 SCP server(s).

Infectious Disease Analysis - Analyze infectious disease: virus data, taxonomy, antimicrobial drugs, and resistance literature. Use this skill for infectious disease tasks involving get virus dataset report get taxonomy get mechanism of action by drug name pubmed search. Combines 4 tools from 3 SCP server(s).

Metabolomics Pathway Analysis - Analyze metabolomics: compound identification, KEGG pathway mapping, enzyme links, and PubChem data. Use this skill for metabolomics tasks involving search pubchem by name kegg find kegg link kegg get. Combines 4 tools from 2 SCP server(s).

Drug Warning Intelligence Report - Generate drug warning report: ChEMBL drug warnings, FDA boxed warnings, adverse reactions, and environmental warnings. Use this skill for pharmacovigilance tasks involving get drug warning by id get boxed warning info by drug name get adverse reactions by drug name get environmental warning by drug name. Combines 4 tools from 2 SCP server(s).

Gene Comprehensive Lookup - Comprehensive gene lookup: NCBI gene data, Ensembl gene info, UniProt protein data, and KEGG pathway links. Use this skill for bioinformatics tasks involving get gene metadata by gene name get lookup symbol get general info by protein or gene name kegg find. Combines 4 tools from 4 SCP server(s).

Calculate atmospheric parameters including Coriolis parameter, geostrophic wind, heat index, potential temperature, and dewpoint for meteorology and climate science.

CAS Number Compound Lookup - Look up compounds by CAS: convert CAS to price/availability, get PubChem data, get ChEMBL info, and structure analysis. Use this skill for chemical information tasks involving CASToPrice get compound by name get molecule by name ChemicalStructureAnalyzer. Combines 4 tools from 4 SCP server(s).

Convert physical quantities and units at nanoscale for materials science and nanotechnology applications.

UniProt Deep Protein Analysis - Deep UniProt analysis: entry data, UniRef clusters, UniParc cross-references, and gene-centric view. Use this skill for protein science tasks involving get uniprotkb entry by accession get uniref cluster by id get uniparc entry by upi get gene centric by accession. Combines 4 tools from 1 SCP server(s).

Assess wind energy potential and perform site analysis using atmospheric science calculations.

Protein Structure Quality Assessment - Assess structure quality: basic info, geometry analysis, quality metrics, composition, and visualization. Use this skill for structural biology tasks involving calculate pdb basic info calculate pdb structural geometry calculate pdb quality metrics calculate pdb composition info visualize protein. Combines 5 tools from 1 SCP server(s).

Cross-Species Protein Comparison - Compare proteins across species: get orthologs from NCBI, compute properties for each, and compare similarity. Use this skill for comparative biology tasks involving get gene orthologs calculate protein sequence properties calculate smiles similarity get homology id. Combines 4 tools from 3 SCP server(s).

Use ESMFold model to predict 3D structure of the input protein sequence.

Antibody Drug Development - Develop antibody drug: target protein analysis, biotherapeutic lookup, protein properties, and interaction prediction. Use this skill for biologics tasks involving get uniprotkb entry by accession get biotherapeutic by name ComputeProtPara ComputeHydrophilicity. Combines 4 tools from 3 SCP server(s).

Calculate the freezing point temperature of seawater from absolute salinity and pressure using GSW thermodynamic equations.

Transcriptome Analysis Pipeline - Analyze transcriptome: Ensembl transcript lookup, sequence retrieval, haplotype analysis, and UCSC track data. Use this skill for transcriptomics tasks involving get lookup id get sequence id get transcript haplotypes get track data. Combines 4 tools from 2 SCP server(s).

Analyze DNA and RNA sequences including molecular weight calculation, reverse complement generation, and oligonucleotide properties.

NCBI Gene Deep Dive - Deep dive into NCBI gene: metadata, dataset report, product report, orthologs, and gene links. Use this skill for gene biology tasks involving get gene metadata by gene name get gene dataset report by id get gene product report by id get gene orthologs get gene links by id. Combines 5 tools from 1 SCP server(s).

Substance Toxicology Report - Toxicology report: PubChem substance data, FDA toxicology, carcinogenicity data, and environmental warnings. Use this skill for toxicology tasks involving get substance by name get nonclinical toxicology info by drug name get carcinogenic mutagenic fertility impairment info by drug name get environmental warning by drug name. Combines 4 tools from 2 SCP server(s).

Antibody-Target Analysis - Analyze an antibody target: UniProt protein info, InterPro domains, protein properties, and biotherapeutic data from ChEMBL. Use this skill for immunology tasks involving get uniprotkb entry by accession query interpro ComputeProtPara get biotherapeutic by name. Combines 4 tools from 4 SCP server(s).

Search ChEMBL database for molecule information by name to retrieve bioactivity data and chemical structures.

Chemical Property Profiling - Profile chemical properties: basic info, hydrophobicity, H-bonds, charges, and molecular complexity. Use this skill for physical chemistry tasks involving calculate mol basic info calculate mol hydrophobicity calculate mol hbond calculate mol charge calculate mol complexity. Combines 5 tools from 1 SCP server(s).

Proteome-Level Analysis - Analyze at proteome level: get proteome from UniProt, gene-centric view, functional annotation from STRING. Use this skill for proteomics tasks involving get proteome by id get gene centric by proteome get functional annotation. Combines 3 tools from 2 SCP server(s).

Tissue-Specific Expression Analysis - Analyze tissue-specific expression: ChEMBL tissue data, TCGA cancer expression, Ensembl gene info, and NCBI gene data. Use this skill for tissue biology tasks involving get tissue by id get gene expression across cancers get lookup symbol get gene metadata by gene name. Combines 4 tools from 4 SCP server(s).

Epigenomic Landscape Mapping - Map epigenomic landscape: overlapping features, regulatory elements, binding matrices, and phenotype links. Use this skill for epigenomics tasks involving get overlap region get phenotype region get species binding matrix get track data. Combines 4 tools from 2 SCP server(s).

Structural Pharmacogenomics - Link structure to pharmacogenomics: variant effect, protein structure change, drug binding, and clinical data. Use this skill for pharmacogenomics tasks involving get vep hgvs pred protein structure esmfold boltz binding affinity get pharmacogenomics info by drug name. Combines 4 tools from 3 SCP server(s).

Affinity Maturation Pipeline - Affinity maturation: compute binding affinity, predict mutations, compute hydrophilicity, and predict drug-target interaction. Use this skill for antibody engineering tasks involving ComputeAffinityCalculator zero shot sequence prediction ComputeHydrophilicity PredictDrugTargetInteraction. Combines 4 tools from 3 SCP server(s).

ADMET & Drug-Likeness Report - Generate comprehensive ADMET and drug-likeness report: molecular properties, H-bond analysis, hydrophobicity, topology, and ADMET prediction. Use this skill for medicinal chemistry tasks involving calculate mol basic info calculate mol hbond calculate mol hydrophobicity calculate mol topology pred molecule admet. Combines 5 tools from 2 SCP server(s).

Disease Knowledge Graph - Build disease knowledge graph: OpenTargets targets, drugs, publications, and phenotypes. Use this skill for disease informatics tasks involving get associated targets by disease efoId get associated drugs by target name get publications by drug name get associated phenotypes by disease efoId. Combines 4 tools from 1 SCP server(s).

Predict the ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties of the input molecules.

Enzyme Active Site Engineering - Engineer enzyme: identify active site residues, predict pocket, analyze binding site, and predict mutations. Use this skill for enzymology tasks involving predict functional residue run fpocket get binding site by id pred mutant sequence. Combines 4 tools from 3 SCP server(s).

Gene Ontology Analysis - Analyze GO terms: ChEMBL GO slim, STRING functional enrichment, STRING annotation, and Ensembl ontology. Use this skill for functional genomics tasks involving get go slim by id get functional enrichment get functional annotation get ontology name. Combines 4 tools from 3 SCP server(s).

Use when the user wants the full multi-stage paper discussion workflow, a comprehensive structured discussion of one paper, or an equivalent full-discussion request in another language.

Analyze chemical structures from compound names to retrieve SMILES, molecular formulas, molecular weight, and LogP values.

Retrieve disease-associated targets from Open Targets using disease EFO IDs to identify therapeutic targets.

Personalized Medicine Report - Generate personalized medicine report: pharmacogenomics, variant effects, drug safety, and clinical pharmacology. Use this skill for precision medicine tasks involving get pharmacogenomics info by drug name get vep hgvs get adverse reactions by drug name get clinical pharmacology by drug name. Combines 4 tools from 2 SCP server(s).

Drug-Drug Interaction Checker - Check interactions between multiple drugs using FDA interaction data, PubChem compound info, and ChEMBL target overlap analysis. Use this skill for clinical pharmacology tasks involving get drug interactions by drug name get compound by name get target by name. Combines 3 tools from 3 SCP server(s).

Polymer & Material Property Analysis - Analyze polymer properties: composition, symmetry, density, and lattice parameters for material design. Use this skill for polymer science tasks involving MaterialCompositionAnalyzer CalculateSymmetry CalculateDensity MofLattice. Combines 4 tools from 2 SCP server(s).

Cross-Database Compound Lookup - Cross-reference compound across databases: PubChem, ChEMBL, KEGG, and CAS number lookup. Use this skill for chemical information tasks involving get compound by name get molecule by name kegg find CASToPrice. Combines 4 tools from 4 SCP server(s).

Virtual Screening Pipeline - Virtual screening: search PubChem by substructure, compute similarity, filter by drug-likeness, and predict binding affinity. Use this skill for drug discovery tasks involving search pubchem by smiles calculate smiles similarity calculate mol drug chemistry boltz binding affinity. Combines 4 tools from 3 SCP server(s).

Retrieve protein sequences and functional information from UniProt database by protein name, enabling protein analysis and bioinformatics workflows.

Molecular Visualization Suite - Visualize molecules: convert SMILES to formats, visualize molecule, visualize protein, visualize complex. Use this skill for chemical visualization tasks involving convert smiles to format visualize molecule visualize protein visualize complex. Combines 4 tools from 1 SCP server(s).

Clinical Pharmacology Report - Generate clinical pharmacology report: PK, PD, mechanism, drug interactions, and special populations. Use this skill for clinical pharmacology tasks involving get pharmacokinetics by drug name get pharmacodynamics by drug name get mechanism of action by drug name get drug interactions by drug name get geriatric use info by drug name. Combines 5 tools from 1 SCP server(s).

Calculate electrical capacitance from geometric parameters and dielectric properties for circuit design.

Multi-Unit Conversion Suite - Convert units across domains: length mm to m, radius m to cm, dimensions to meters, nm to um, volume to cm3. Use this skill for metrology tasks involving convert length mm to m convert radius m to cm convert dimensions to meters convert nm to um convert volume to cm3. Combines 5 tools from 1 SCP server(s).

Variant Pathogenicity Assessment - Assess variant pathogenicity: Ensembl VEP prediction, ClinVar lookup, variation details, and gene phenotype associations. Use this skill for clinical genetics tasks involving get vep hgvs clinvar search get variation get phenotype gene. Combines 4 tools from 2 SCP server(s).

Chemical Patent & Novelty Analysis - Analyze chemical novelty: PubChem substructure CAS search, ChEMBL similarity search, compound synonyms, and literature. Use this skill for patent chemistry tasks involving get substructure cas get similarity by smiles get compound synonyms by name search literature. Combines 4 tools from 3 SCP server(s).

Create new skills, improve existing skills, and measure skill performance. Use when users want to create a skill from scratch, update or optimize an existing skill, run evals to test a skill, or benchmark skill performance with variance analysis.

Disease-Specific Compound Screening - Screen compounds for disease: get DLEPS score for disease relevance, predict ADMET, and check drug-likeness. Use this skill for drug discovery tasks involving calculate dleps score pred molecule admet calculate mol drug chemistry get compound by name. Combines 4 tools from 3 SCP server(s).

Regulatory Region Analysis - Analyze regulatory regions: get overlapping features, binding matrix, sequence, and phenotype associations. Use this skill for epigenomics tasks involving get overlap region get species binding matrix get sequence get phenotype region. Combines 4 tools from 2 SCP server(s).

Retrieve gene expression data from TCGA (The Cancer Genome Atlas) to analyze cancer-specific expression patterns.

Cell Line Assay Analysis - Analyze cell line assays: ChEMBL cell line info, assay search, activity data, and target info. Use this skill for cell biology tasks involving get cell line by id search assay search activity get target by name. Combines 4 tools from 1 SCP server(s).

Cancer Therapy Design - Design cancer therapy: identify targets, find drugs, check safety, and analyze differential expression. Use this skill for oncology tasks involving get associated targets by disease efoId get associated drugs by target name get adverse reactions by drug name tcga differential expression analysis. Combines 4 tools from 3 SCP server(s).

Retrieve SMILES strings from PubChem database using compound names to obtain molecular structures from common chemical names.

Organism Classification & Database - Classify organism: NCBI taxonomy, Ensembl taxonomy, ChEMBL organisms, and genome info. Use this skill for taxonomy tasks involving get taxonomy get taxonomy id get organism by id get genome dataset report by taxon. Combines 4 tools from 3 SCP server(s).

Protein Solubility Optimization - Optimize protein solubility: calculate properties, predict solubility, predict hydrophilicity, and suggest mutations. Use this skill for protein engineering tasks involving calculate protein sequence properties predict protein function ComputeHydrophilicity zero shot sequence prediction. Combines 4 tools from 3 SCP server(s).

Pediatric Drug Safety Review - Evaluate pediatric drug safety: pediatric use info, child safety, dosage forms, and overdosage info from FDA. Use this skill for pediatric pharmacology tasks involving get pediatric use info by drug name get child safety info by drug name get dosage forms and strengths by drug name get overdosage info by drug name. Combines 4 tools from 1 SCP server(s).

Full Protein Characterization - Complete protein characterization: validate sequence, compute all properties, predict structure, and analyze pockets. Use this skill for protein biochemistry tasks involving is valid protein sequence analyze protein ComputeProtPara pred protein structure esmfold run fpocket. Combines 5 tools from 4 SCP server(s).

Protein Similarity Search - Search for similar proteins: extract sequence from PDB, search structures with FoldSeek, find homologs with STRING, and check UniProt. Use this skill for bioinformatics tasks involving extract pdb sequence foldseek search get best similarity hits between species search uniprotkb entries. Combines 4 tools from 3 SCP server(s).

Compound-to-Drug Analysis Pipeline - Full compound-to-drug pipeline: name-to-SMILES conversion, structure analysis, drug-likeness, and FDA drug lookup. Use this skill for drug development tasks involving NameToSMILES ChemicalStructureAnalyzer calculate mol drug chemistry get drug by name. Combines 4 tools from 4 SCP server(s).

Retrieve genomic sequences from Ensembl database using transcript or gene IDs to obtain nucleotide and protein sequences.

ATC Drug Classification Lookup - Look up drug in ATC classification: ChEMBL ATC class, FDA drug info, PubChem compound, and mechanism of action. Use this skill for pharmacology tasks involving get atc class by level5 get mechanism of action by drug name get compound by name get drug by name. Combines 4 tools from 3 SCP server(s).

Gene Family Evolution Analysis - Analyze gene family evolution: CAFE gene tree, homology, Ensembl gene tree, and taxonomy. Use this skill for molecular evolution tasks involving get cafe genetree member symbol get homology symbol get genetree member symbol get taxonomy classification. Combines 4 tools from 1 SCP server(s).

Implement data transmission between the local computer and the MCP Server using Base64 encoding

Protein Function Annotation Pipeline - Annotate protein function: UniProt metadata, InterPro domains, functional prediction, and GO enrichment. Use this skill for proteomics tasks involving query uniprot query interpro predict protein function get functional enrichment. Combines 4 tools from 2 SCP server(s).

Use when the user wants question-driven help on one paper, including paper understanding, follow-up questions, method or experiment clarification, limitation analysis, or comparison against related work in any language.

InterProScan Analysis Pipeline - Run InterProScan for domain analysis, then enrich with UniProt data and STRING interactions. Use this skill for functional proteomics tasks involving interproscan analyze get uniprotkb entry by accession get functional enrichment query interpro. Combines 4 tools from 4 SCP server(s).

Calculate mass percentages and stoichiometric ratios for chemical reactions and compound compositions.

Query gnomAD for variant allele frequency across populations. Uses FAVOR to convert rsID→variant_id first, then queries gnomAD.

Clinical Trial Drug Profiling - Profile drug for clinical trials: FDA clinical studies, contraindications, pregnancy info, and geriatric use. Use this skill for clinical research tasks involving get clinical studies info by drug name get contraindications by drug name get pregnancy effects info by drug name get geriatric use info by drug name. Combines 4 tools from 1 SCP server(s).

Propose a new change with all artifacts generated in one step. Use when the user wants to quickly describe what they want to build and get a complete proposal with design, specs, and tasks ready for implementation.

Mouse Model Disease Analysis - Analyze mouse disease models: MouseMine search, NCBI mouse gene data, Ensembl cross-species comparison, and orthologs. Use this skill for model organisms tasks involving mousemine search get gene metadata by gene name get homology symbol get gene orthologs. Combines 4 tools from 3 SCP server(s).

Generate detailed laboratory protocols from natural language descriptions using AI, producing step-by-step experimental procedures ready for lab execution.

Lab Protocol from Literature - Extract and generate lab protocol: search PubMed, extract protocol from paper, and generate executable protocol. Use this skill for lab science tasks involving pubmed search extract protocol from pdf protocol generation generate executable json. Combines 4 tools from 2 SCP server(s).

PubChem Deep Dive Analysis - Deep dive into PubChem: compound info, bioassay summary, 3D conformers, synonyms, and general description. Use this skill for chemical databases tasks involving get pubchem compound by cid get assay summary by cid get conformers by cid get compound synonyms by name get general info by compound name. Combines 5 tools from 1 SCP server(s).

Microbiome Genomics Analysis - Analyze microbial genome: NCBI genome data, taxonomy, KEGG metabolic pathways, and annotation. Use this skill for metagenomics tasks involving get genome dataset report by taxon get taxonomy kegg find get genome annotation report. Combines 4 tools from 2 SCP server(s).

Convert laboratory protocols to executable JSON format using Thoth-OP for automated lab equipment control.

BLAST & Protein Analysis Pipeline - BLAST search followed by comprehensive protein analysis: BLAST, then structure prediction, properties, and function. Use this skill for sequence bioinformatics tasks involving blast search pred protein structure esmfold calculate protein sequence properties predict protein function. Combines 4 tools from 4 SCP server(s).

Drug-Indication Mapping - Map drug indications: ChEMBL drug indications, FDA indications, OpenTargets drug associations, and literature. Use this skill for clinical informatics tasks involving get drug indication by id get indications by drug name get associated drugs by target name pubmed search. Combines 4 tools from 4 SCP server(s).

Gene Expression Atlas - Build gene expression atlas: TCGA cancer expression, NCBI gene info, Ensembl gene details, and literature search. Use this skill for transcriptomics tasks involving get gene expression across cancers get gene metadata by gene name get lookup symbol search literature. Combines 4 tools from 4 SCP server(s).

Gene-to-Drug Discovery Pipeline - Full gene-to-drug pipeline: gene lookup, protein structure, binding pocket, virtual screening, and drug-likeness. Use this skill for translational medicine tasks involving get gene metadata by gene name pred protein structure esmfold run fpocket boltz binding affinity calculate mol drug chemistry. Combines 5 tools from 3 SCP server(s).

Optical System Analysis - Analyze optical system: calculate photon rate, frequency range, radiation pressure, and electron wavelength. Use this skill for optics tasks involving calculate incident photon rate calculate frequency range calculate radiation pressure electron wavelength. Combines 4 tools from 1 SCP server(s).

Biomarker Discovery Pipeline - Discover biomarkers: TCGA differential expression, NCBI gene data, OpenTargets associations, and clinical relevance. Use this skill for precision medicine tasks involving tcga differential expression analysis get gene metadata by gene name get associated targets by disease efoId clinvar search. Combines 4 tools from 4 SCP server(s).

Virus Genomics Analysis - Analyze virus genomics: NCBI virus dataset, annotation, taxonomy, and literature search. Use this skill for virology tasks involving get virus dataset report get virus annotation report get taxonomy search literature. Combines 4 tools from 2 SCP server(s).

Calculate material density and volume from mass and geometric dimensions for materials mechanics analysis.

Analyze measurement errors, uncertainties, and statistical variations in experimental data for quality control.

Computational Analysis via Code Execution - Execute custom computational analysis code, analyze software, and search for reference implementations. Use this skill for computational science tasks involving exec code software analysis search dataset search literature. Combines 4 tools from 2 SCP server(s).

Calculate optical frequency and wavelength relationships for photonics and electromagnetic analysis.

Use when the user wants a sharp reviewer-style critique of a batch of papers, including triage into must-read versus skippable papers, blunt per-paper criticism, or similar Chinese requests for a daily roast of papers.

Analyze protein-protein interaction enrichment using STRING database to identify functional networks and pathway associations.

Population Genetics Analysis - Analyze population genetics: Ensembl variation populations, linkage disequilibrium, and variant frequency data. Use this skill for population genetics tasks involving get info variation populations get ld get variation get variant recoder. Combines 4 tools from 1 SCP server(s).

Mutation Impact Analysis - Analyze mutation impact: predict structure, predict mutations from sequence and structure, and check variant effects with Ensembl VEP. Use this skill for molecular biology tasks involving pred protein structure esmfold zero shot sequence prediction predict zero shot structure get vep hgvs. Combines 4 tools from 3 SCP server(s).

Calculate seawater thermodynamic properties using TEOS-10 standard including density, salinity, sound speed, and freezing temperature for oceanography.

Chromosome Structure Analysis - Analyze chromosome: NCBI summary, UCSC cytoband, genome sequence, and Ensembl assembly info. Use this skill for cytogenetics tasks involving get chromosome summary get cytoband get chromosome sequence get info assembly. Combines 4 tools from 3 SCP server(s).

Polypharmacology Analysis - Analyze a drug's multi-target pharmacology: get targets from ChEMBL, functional enrichment from STRING, and pathway links from KEGG. Use this skill for pharmacology tasks involving get target by name get functional enrichment kegg link get mechanism by id. Combines 4 tools from 3 SCP server(s).

Natural Product Analysis - Analyze natural products: name to SMILES, PubChem lookup, structural analysis, and KEGG natural product search. Use this skill for natural products chemistry tasks involving NameToSMILES search pubchem by name ChemicalStructureAnalyzer kegg find. Combines 4 tools from 4 SCP server(s).

Calculate buoyancy forces and acceleration for fluid mechanics and hydrodynamics analysis.

Calculate different types of molecular properties based on SMILES strings, covering basic physicochemical properties, hydrophobicity, hydrogen bonding capability, molecular complexity, topological structures, charge distribution, and custom complexity metrics, respectively.

Binding Site Characterization - Characterize binding sites: predict pockets with fpocket and P2Rank, get binding site info from ChEMBL, and visualize. Use this skill for structural biology tasks involving run fpocket pred pocket prank get binding site by id visualize protein. Combines 4 tools from 3 SCP server(s).

Synthetic Biology Design - Design synthetic biology construct: gene lookup, codon optimization, protein property prediction, and structure prediction. Use this skill for synthetic biology tasks involving get sequence id DegenerateCodonCalculatorbyAminoAcid calculate protein sequence properties pred protein structure esmfold. Combines 4 tools from 4 SCP server(s).

Search KEGG database for gene information to retrieve pathway associations, functional annotations, and disease links.

Given a protein sequence and its structure, employ ProSST model to predict mutation effects and obtain the top-k mutated sequences.

Substructure-Activity Relationship - Analyze substructure-activity: ChEMBL substructure search, activity data, PubChem compounds, and similarity. Use this skill for medicinal chemistry tasks involving get substructure by smiles search activity search pubchem by smiles calculate smiles similarity. Combines 4 tools from 3 SCP server(s).

Comprehensive Drug Safety Profile - Build a complete drug safety profile by combining FDA adverse reactions, boxed warnings, drug interactions, and contraindications. Use this skill for pharmacology tasks involving get adverse reactions by drug name get boxed warning info by drug name get drug interactions by drug name get contraindications by drug name. Combines 4 tools from 1 SCP server(s).

Propose a new change - create it and generate all artifacts in one step

Use the local InnoClaw CLI to run app workflows and Deep Research sessions from the terminal. Trigger when the user wants command-line control over this repository instead of only using the web UI.

Convert a file containing identified issues into GitHub issues. Use after running identify-* commands to create corresponding GitHub issues.

Write high quality, user-facing documentation. Use any time you need to write, improve, or update a significant amount of user-facing documentation (e.g., files in a "docs/" folder or README file).

Identify divergences from the style guide in the $1 library

Send a message to another mngr agent. Use when you need to communicate with a peer agent.

Identify places in the $1 library where the docs and code disagree

Convert a file containing identified issues into a tracked file in current_tasks/. Use after running identify-* commands to create a local record of current issues.

Create a new PRIVATE GitHub repo that is a full-history copy of imbue-ai/forever-claude-template's current main branch, clone it to <parent-dir>/<repo-name> (default $HOME/project), and push. Use when the user asks to "spin up a new forever-claude clone", "fork the forever-claude template as a private repo", "make me a new private copy of forever-claude-template", or similar.

Identify outdated docstrings in the $1 library

Write high quality specifications or design docs for a program. Use any time you are asked to write, improve, or update specs / design docs (e.g., files in a `specs/` folder).

Identify inconsistencies in the $1 library

Cut a new "production" release of the minds app. Pushes a release branch in the mngr clone at ~/project/minds_prod, syncs vendor/mngr in ~/project/forever-claude-template to match, pushes the same-named branch there, and merges the release branch into FCT main. Use when the user asks to "release a new version of minds", "cut a minds release", "update the vendored mngr in forever-claude-template to track <branch>", or anything of that shape.

智能软件著作权申请材料生成工具。自动分析项目源码，生成符合软著申请要求的软件说明书和源代码文档。支持关键词搜索、智能源码分析、格式化输出和PDF导出。

Habilidad para crear storyboards (tableros visuales) a partir de guiones de video usando generación de imágenes con IA. Se activa con 'Crear un storyboard', 'Generar storyboard', 'Crear imágenes desde guión', etc.

Habilidad de planificacion para apoyar pruebas A/B de contenido y ciclos de auto-mejora. Cubre el ciclo completo de investigacion de tendencias de mercado -> generacion de hipotesis -> diseno de experimentos -> recopilacion de metricas -> analisis y mejora. Se activa con solicitudes como 'optimizar contenido', 'mejorar publicaciones', 'crear ideas de publicaciones a partir del analisis de tendencias', 'mejorar engagement', etc.

Guía de diseño UI/UX. Soporta 50 estilos, 97 paletas, 57 combinaciones de fuentes y 9 stacks. Se activa con solicitudes como 'Diseñar la interfaz', 'Crear un sistema de diseño', 'Revisión de pantalla', etc.

Habilidad que genera páginas SEO a escala utilizando plantillas y datos. Se activa con solicitudes como 'Quiero producir páginas SEO en masa', 'Crear páginas de plantilla', 'Crear páginas por región'.

Habilidad que busca datos sincronizados de Slack para menciones y extrae TODOs/tareas con determinación de estado. Se activa con solicitudes como 'Extraer tareas de Slack', 'Verificar TODOs', 'Verificar menciones'.

Realiza búsquedas en tiempo real en X (Twitter) para recopilar y analizar tweets sobre un tema. Produce resultados de búsqueda como informes estructurados (Markdown + JSON + TXT). Se activa con 'Buscar en X', 'Investigar en Twitter', 'Analizar tweets', etc.

Habilidad para crear y mejorar textos de marketing para páginas de destino, páginas de inicio, páginas de precios, entre otras. Se activa con solicitudes como 'escribe el copy,' 'crea el copy del LP,' 'piensa en un titular,' etc. Para textos de correo electrónico, consulte email-sequence. Para textos de popup, consulte popup-cro.

Habilidad para escribir SQL preciso y de alto rendimiento en los principales dialectos de almacenes de datos. Se activa con solicitudes como 'Escribir SQL', 'Optimizar consulta', 'Agregar en BigQuery', etc.

Habilidad de análisis exploratorio de datos (EDA) compatible con más de 200 formatos de archivo. Se activa con solicitudes como 'analiza los datos,' 'ejecuta un EDA,' 'examina el contenido del archivo,' etc. Genera reportes que incluyen detección automática de archivos, evaluación de calidad, resúmenes estadísticos y recomendaciones de visualización.

Habilidad de creacion de contenido de marketing. Crea publicaciones de X/Instagram, articulos de Note/Medium, imagenes de banner, guiones de video y mas. Se activa con solicitudes como 'crear una publicacion', 'crear un banner', 'escribir un articulo', 'crear copia', etc. Referencia product-context.md para mantener consistencia de marca.

Sub-agente que realiza conexiones a BigQuery/Snowflake, EDA, visualización y creación de notebooks Marimo. Integra cuatro reglas relacionadas (data_analysis, visualization, notebook, marimo_variable_naming). Se activa con solicitudes como 'analiza datos,' 'conectar a BigQuery,' 'ejecutar EDA,' 'analizar con Marimo,' etc.

Skill de formulación de planes de marketing y creación de contexto de marketing de producto. Se activa con 'plan de marketing', 'posicionamiento', 'creación de persona', 'análisis competitivo', etc. Genera product-marketing-context.md para servir como base de otros skills de marketing.

Habilidad de generación de guiones y storyboards para videos virales de TikTok/YouTube Shorts. Incorpora automáticamente técnicas virales investigadas (gancho de 3 segundos, estructura modular, puente de loop, texto flash, pantalla dividida, etc.) en la creación de guiones y storyboards. Se activa con 'Guión de video TikTok', 'Quiero hacer un video viral', 'Guión de video corto', etc.

Habilidad para editar, revisar y mejorar textos de marketing. Se activa con solicitudes como 'edita el texto,' 'corrige la redacción,' 'retroalimentación del copy,' etc. Un enfoque de edición sistemático mediante múltiples pasadas enfocadas.

Sub-agente para generar y editar banners, diagramas, diapositivas e imágenes. Usa la API de Generación de Imágenes de Gemini para generar diversos medios. Se activa con solicitudes como 'crear un banner', 'generar un diagrama', 'crear diapositivas', 'generar una imagen', etc.

Agente de corrección de artículos en japonés. Verifica errores tipográficos, gramática, consistencia de expresiones y legibilidad, generando sugerencias de corrección como anotaciones en línea. Se activa con solicitudes como 'Corregir esto', 'Verificar el texto', 'Buscar errores tipográficos', 'Revisar el artículo'.

Skill para generar automáticamente actas de reunión estructuradas a partir de texto y notas de reuniones. Se activa con solicitudes como 'resumir las actas', 'organizar notas de reunión', 'extraer elementos de acción', etc.

Habilidad de redaccion de articulos que genera esquemas a partir de temas, aplica perfiles de estilo y produce articulos en Markdown. Soporta insercion automatica de marcadores de ilustracion y unificacion de estilo a traves de perfiles de style-analyzer. Se activa con solicitudes como 'escribir un articulo', 'crear un blog', 'generar articulo del tema', etc.

Habilidad para planificar estrategias de contenido, seleccionar temas y decidir temáticas de artículos. Se activa con solicitudes como 'planifica una estrategia de contenido', '¿qué debería escribir?', 'piensa en temas para el blog', etc. Para redactar piezas individuales, consulte copywriting. Para auditorías específicas de SEO, consulte seo-audit.

Habilidad para apoyar la configuracion, mejora y auditoria del seguimiento analitico. Se activa con solicitudes como 'configurar seguimiento', 'implementar GA4', 'seguimiento de conversiones', 'seguimiento de eventos', 'parametros UTM', 'configuracion de GTM', etc. Para seguimiento de pruebas A/B, consulte ab-test-setup.

Skill para diseñar y optimizar campañas de publicidad pagada en Google Ads, Meta, LinkedIn, etc. Se activa con solicitudes como 'quiero poner anuncios', 'crear una campaña publicitaria', 'retargeting', etc.

Lee múltiples textos existentes del usuario, extrae características del estilo de escritura (patrones de terminación de oraciones, longitud de oraciones, ratio kanji/hiragana, tono, tendencias de conjunciones) y genera un perfil de estilo. Se activa con solicitudes como 'Analizar estilo de escritura', 'Imitar esta escritura', 'Aprender estilo de escritura', etc.

Habilidad para generar banners/creativos para diversas plataformas de redes sociales y publicidad. Compatible con X, Facebook, Instagram, PRTimes, YouTube, LINE y anuncios web. Se activa con solicitudes como 'crear un banner', 'generar imagen publicitaria', 'imagen para redes sociales', 'produccion creativa', etc.

Habilidad que agrega, corrige y optimiza datos estructurados y marcado schema. Se activa con solicitudes como 'Agregar datos estructurados', 'Crear JSON-LD', 'Configurar fragmentos enriquecidos'.

Flujo de trabajo para creación de LP/HP. Guía el flujo completo desde entrevista → organización de mensajes → wireframe → diseño en Pencil → implementación HTML → despliegue en Vercel. Se activa con solicitudes como 'crear un LP', 'creación de landing page', 'diseño de HP', 'producción de página web', etc.

Habilidad de edición de video para TikTok/YouTube. Incrusta subtítulos con ffmpeg, aplica efectos Ken Burns, combina escenas y sintetiza audio. Lee instrucciones de edición de scenes.json y produce el video final. También incluye componentes Remotion (para entornos locales). Se activa con 'Editar video', 'Agregar subtítulos', 'Crear video con subtítulos', etc.

Habilidad que extrae automáticamente afirmaciones factuales (números, fechas, nombres propios, estadísticas) de artículos y las verifica mediante búsqueda web. Se activa con solicitudes como 'verifica los hechos,' 'confirma la información,' 'comprueba las fuentes,' etc. Genera un reporte con puntuaciones de confianza.

Habilidad que diseña y optimiza programas de referidos, programas de afiliados y estrategias de boca a boca. Se activa con solicitudes como 'Quiero crear un programa de referidos', 'Diseño de afiliados', 'Pensar en estrategias de boca a boca'.

Habilidad integrada para extraer elementos accionables y tareas del correo electronico y Slack. Utiliza Gemini 3.0 Flash para analisis de contexto, generando prioridades y borradores de respuesta. Se activa con solicitudes como 'revisar bandeja de entrada', 'verificar TODOs', 'mensajes por responder', 'revisar correo', etc.

Full lifecycle team skill — plan, develop, test, review in one coordinated session. Role-based architecture with coordinator-driven beat model. Triggers on "team lifecycle v4".

Meta-skill for designing orchestrator+phases structured workflow skills. Creates SKILL.md coordinator with progressive phase loading, TodoWrite patterns, and data flow. Triggers on "design workflow skill", "create workflow skill", "workflow skill designer".

Manifest-driven knowledge asset generator — converts any structured package into maestro knowhow + spec entries with ref linking. Triggers on "codify-to-knowhow", "style to knowhow", "知识固化".

Create or sync milestone worktree for parallel dev

Bump version, generate changelog, tag milestone

Generate overlays to fix workflow command deficiencies

Extract knowledge from artifacts into wiki/spec/issues

Extract design system from code, generate reference package, persist as knowledge assets