For backend engineers

Use when encountering any bug, test failure, or unexpected behavior, before proposing fixes

Use when receiving code review feedback, before implementing suggestions, especially if feedback seems unclear or technically questionable - requires technical rigor and verification, not performative agreement or blind implementation

Use when about to claim work is complete, fixed, or passing, before committing or creating PRs - requires running verification commands and confirming output before making any success claims; evidence before assertions always

Build, debug, and optimize Claude API / Anthropic SDK apps. Apps built with this skill should include prompt caching. Also handles migrating existing Claude API code between Claude model versions (4.5 → 4.6, 4.6 → 4.7, retired-model replacements). TRIGGER when: code imports `anthropic`/`@anthropic-ai/sdk`; user asks for the Claude API, Anthropic SDK, or Managed Agents; user adds/modifies/tunes a Claude feature (caching, thinking, compaction, tool use, batch, files, citations, memory) or model (Opus/Sonnet/Haiku) in a file; questions about prompt caching / cache hit rate in an Anthropic SDK project. SKIP: file imports `openai`/other-provider SDK, filename like `*-openai.py`/`*-generic.py`, provider-neutral code, general programming/ML.

Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

Knowledge and utilities for creating animated GIFs optimized for Slack. Provides constraints, validation tools, and animation concepts. Use when users request animated GIFs for Slack like "make me a GIF of X doing Y for Slack."

Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.

Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel. Use it when brand colors or style guidelines, visual formatting, or company design standards apply.

Fast headless browser for QA testing and site dogfooding. Navigate pages, interact with elements, verify state, diff before/after, take annotated screenshots, test responsive layouts, forms, uploads, dialogs, and capture bug evidence. Use when asked to open or test a site, verify a deployment, dogfood a user flow, or file a bug with screenshots. (gstack)

Auto-review pipeline — reads the full CEO, design, eng, and DX review skills from disk and runs them sequentially with auto-decisions using 6 decision principles. Surfaces taste decisions (close approaches, borderline scope, codex disagreements) at a final approval gate. One command, fully reviewed plan out. Use when asked to "auto review", "autoplan", "run all reviews", "review this plan automatically", or "make the decisions for me". Proactively suggest when the user has a plan file and wants to run the full review gauntlet without answering 15-30 intermediate questions. (gstack) Voice triggers (speech-to-text aliases): "auto plan", "automatic review".

Performance regression detection using the browse daemon. Establishes baselines for page load times, Core Web Vitals, and resource sizes. Compares before/after on every PR. Tracks performance trends over time. Use when: "performance", "benchmark", "page speed", "lighthouse", "web vitals", "bundle size", "load time". (gstack) Voice triggers (speech-to-text aliases): "speed test", "check performance".

Cross-model benchmark for gstack skills. Runs the same prompt through Claude, GPT (via Codex CLI), and Gemini side-by-side — compares latency, tokens, cost, and optionally quality via LLM judge. Answers "which model is actually best for this skill?" with data instead of vibes. Separate from /benchmark, which measures web page performance. Use when: "benchmark models", "compare models", "which model is best for X", "cross-model comparison", "model shootout". (gstack) Voice triggers (speech-to-text aliases): "compare models", "model shootout", "which model is best".

Fast headless browser for QA testing and site dogfooding. Navigate any URL, interact with elements, verify page state, diff before/after actions, take annotated screenshots, check responsive layouts, test forms and uploads, handle dialogs, and assert element states. ~100ms per command. Use when you need to test a feature, verify a deployment, dogfood a user flow, or file a bug with evidence. Use when asked to "open in browser", "test the site", "take a screenshot", or "dogfood this". (gstack)

Post-deploy canary monitoring. Watches the live app for console errors, performance regressions, and page failures using the browse daemon. Takes periodic screenshots, compares against pre-deploy baselines, and alerts on anomalies. Use when: "monitor deploy", "canary", "post-deploy check", "watch production", "verify deploy". (gstack)

Safety guardrails for destructive commands. Warns before rm -rf, DROP TABLE, force-push, git reset --hard, kubectl delete, and similar destructive operations. User can override each warning. Use when touching prod, debugging live systems, or working in a shared environment. Use when asked to "be careful", "safety mode", "prod mode", or "careful mode". (gstack)

OpenAI Codex CLI wrapper — three modes. Code review: independent diff review via codex review with pass/fail gate. Challenge: adversarial mode that tries to break your code. Consult: ask codex anything with session continuity for follow-ups. The "200 IQ autistic developer" second opinion. Use when asked to "codex review", "codex challenge", "ask codex", "second opinion", or "consult codex". (gstack) Voice triggers (speech-to-text aliases): "code x", "code ex", "get another opinion".

Launch GStack Browser — AI-controlled Chromium with the sidebar extension baked in. Opens a visible browser window where you can watch every action in real time. The sidebar shows a live activity feed and chat. Anti-bot stealth built in. Use when asked to "open gstack browser", "launch browser", "connect chrome", "open chrome", "real browser", "launch chrome", "side panel", or "control my browser". Voice triggers (speech-to-text aliases): "show me the browser".

Restore working context saved earlier by /context-save. Loads the most recent saved state (across all branches by default) so you can pick up where you left off — even across Conductor workspace handoffs. Use when asked to "resume", "restore context", "where was I", or "pick up where I left off". Pair with /context-save. Formerly /checkpoint resume — renamed because Claude Code treats /checkpoint as a native rewind alias in current environments. (gstack)

Save working context. Captures git state, decisions made, and remaining work so any future session can pick up without losing a beat. Use when asked to "save progress", "save state", "context save", or "save my work". Pair with /context-restore to resume later. Formerly /checkpoint — renamed because Claude Code treats /checkpoint as a native rewind alias in current environments, which was shadowing this skill. (gstack)

Chief Security Officer mode. Infrastructure-first security audit: secrets archaeology, dependency supply chain, CI/CD pipeline security, LLM/AI security, skill supply chain scanning, plus OWASP Top 10, STRIDE threat modeling, and active verification. Two modes: daily (zero-noise, 8/10 confidence gate) and comprehensive (monthly deep scan, 2/10 bar). Trend tracking across audit runs. Use when: "security audit", "threat model", "pentest review", "OWASP", "CSO review". (gstack) Voice triggers (speech-to-text aliases): "see-so", "see so", "security review", "security check", "vulnerability scan", "run security".

Design consultation: understands your product, researches the landscape, proposes a complete design system (aesthetic, typography, color, layout, spacing, motion), and generates font+color preview pages. Creates DESIGN.md as your project's design source of truth. For existing sites, use /plan-design-review to infer the system instead. Use when asked to "design system", "brand guidelines", or "create DESIGN.md". Proactively suggest when starting a new project's UI with no existing design system or DESIGN.md. (gstack)

Design finalization: generates production-quality Pretext-native HTML/CSS. Works with approved mockups from /design-shotgun, CEO plans from /plan-ceo-review, design review context from /plan-design-review, or from scratch with a user description. Text actually reflows, heights are computed, layouts are dynamic. 30KB overhead, zero deps. Smart API routing: picks the right Pretext patterns for each design type. Use when: "finalize this design", "turn this into HTML", "build me a page", "implement this design", or after any planning skill. Proactively suggest when user has approved a design or has a plan ready. (gstack) Voice triggers (speech-to-text aliases): "build the design", "code the mockup", "make it real".

Designer's eye QA: finds visual inconsistency, spacing issues, hierarchy problems, AI slop patterns, and slow interactions — then fixes them. Iteratively fixes issues in source code, committing each fix atomically and re-verifying with before/after screenshots. For plan-mode design review (before implementation), use /plan-design-review. Use when asked to "audit the design", "visual QA", "check if it looks good", or "design polish". Proactively suggest when the user mentions visual inconsistencies or wants to polish the look of a live site. (gstack)

Design shotgun: generate multiple AI design variants, open a comparison board, collect structured feedback, and iterate. Standalone design exploration you can run anytime. Use when: "explore designs", "show me options", "design variants", "visual brainstorm", or "I don't like how this looks". Proactively suggest when the user describes a UI feature but hasn't seen what it could look like. (gstack)

Live developer experience audit. Uses the browse tool to actually TEST the developer experience: navigates docs, tries the getting started flow, times TTHW, screenshots error messages, evaluates CLI help text. Produces a DX scorecard with evidence. Compares against /plan-devex-review scores if they exist (the boomerang: plan said 3 minutes, reality says 8). Use when asked to "test the DX", "DX audit", "developer experience test", or "try the onboarding". Proactively suggest after shipping a developer-facing feature. (gstack) Voice triggers (speech-to-text aliases): "dx audit", "test the developer experience", "try the onboarding", "developer experience test".

Post-ship documentation update. Reads all project docs, cross-references the diff, updates README/ARCHITECTURE/CONTRIBUTING/CLAUDE.md to match what shipped, polishes CHANGELOG voice, cleans up TODOS, and optionally bumps VERSION. Use when asked to "update the docs", "sync documentation", or "post-ship docs". Proactively suggest after a PR is merged or code is shipped. (gstack)

Restrict file edits to a specific directory for the session. Blocks Edit and Write outside the allowed path. Use when debugging to prevent accidentally "fixing" unrelated code, or when you want to scope changes to one module. Use when asked to "freeze", "restrict edits", "only edit this folder", or "lock down edits". (gstack)

Upgrade gstack to the latest version. Detects global vs vendored install, runs the upgrade, and shows what's new. Use when asked to "upgrade gstack", "update gstack", or "get latest version". Voice triggers (speech-to-text aliases): "upgrade the tools", "update the tools", "gee stack upgrade", "g stack upgrade".

Full safety mode: destructive command warnings + directory-scoped edits. Combines /careful (warns before rm -rf, DROP TABLE, force-push, etc.) with /freeze (blocks edits outside a specified directory). Use for maximum safety when touching prod or debugging live systems. Use when asked to "guard mode", "full safety", "lock it down", or "maximum safety". (gstack)

Code quality dashboard. Wraps existing project tools (type checker, linter, test runner, dead code detector, shell linter), computes a weighted composite 0-10 score, and tracks trends over time. Use when: "health check", "code quality", "how healthy is the codebase", "run all checks", "quality score". (gstack)

Systematic debugging with root cause investigation. Four phases: investigate, analyze, hypothesize, implement. Iron Law: no fixes without root cause. Use when asked to "debug this", "fix this bug", "why is this broken", "investigate this error", or "root cause analysis". Proactively invoke this skill (do NOT debug directly) when the user reports errors, 500 errors, stack traces, unexpected behavior, "it was working yesterday", or is troubleshooting why something stopped working. (gstack)

Land and deploy workflow. Merges the PR, waits for CI and deploy, verifies production health via canary checks. Takes over after /ship creates the PR. Use when: "merge", "land", "deploy", "merge and verify", "land it", "ship it to production". (gstack)

Manage project learnings. Review, search, prune, and export what gstack has learned across sessions. Use when asked to "what have we learned", "show learnings", "prune stale learnings", or "export learnings". Proactively suggest when the user asks about past patterns or wonders "didn't we fix this before?"

Turn any markdown file into a publication-quality PDF. Proper 1in margins, intelligent page breaks, page numbers, cover pages, running headers, curly quotes and em dashes, clickable TOC, diagonal DRAFT watermark. Not a draft artifact — a finished artifact. Use when asked to "make a PDF", "export to PDF", "turn this markdown into a PDF", or "generate a document". (gstack) Voice triggers (speech-to-text aliases): "make this a pdf", "make it a pdf", "export to pdf", "turn this into a pdf", "turn this markdown into a pdf", "generate a pdf", "make a pdf from", "pdf this markdown".

YC Office Hours — two modes. Startup mode: six forcing questions that expose demand reality, status quo, desperate specificity, narrowest wedge, observation, and future-fit. Builder mode: design thinking brainstorming for side projects, hackathons, learning, and open source. Saves a design doc. Use when asked to "brainstorm this", "I have an idea", "help me think through this", "office hours", or "is this worth building". Proactively invoke this skill (do NOT answer directly) when the user describes a new product idea, asks whether something is worth building, wants to think through design decisions for something that doesn't exist yet, or is exploring a concept before any code is written. Use before /plan-ceo-review or /plan-eng-review. (gstack)

Pair a remote AI agent with your browser. One command generates a setup key and prints instructions the other agent can follow to connect. Works with OpenClaw, Hermes, Codex, Cursor, or any agent that can make HTTP requests. The remote agent gets its own tab with scoped access (read+write by default, admin on request). Use when asked to "pair agent", "connect agent", "share browser", "remote browser", "let another agent use my browser", or "give browser access". (gstack) Voice triggers (speech-to-text aliases): "pair agent", "connect agent", "share my browser", "remote browser access".

CEO/founder-mode plan review. Rethink the problem, find the 10-star product, challenge premises, expand scope when it creates a better product. Four modes: SCOPE EXPANSION (dream big), SELECTIVE EXPANSION (hold scope + cherry-pick expansions), HOLD SCOPE (maximum rigor), SCOPE REDUCTION (strip to essentials). Use when asked to "think bigger", "expand scope", "strategy review", "rethink this", or "is this ambitious enough". Proactively suggest when the user is questioning scope or ambition of a plan, or when the plan feels like it could be thinking bigger. (gstack)

Designer's eye plan review — interactive, like CEO and Eng review. Rates each design dimension 0-10, explains what would make it a 10, then fixes the plan to get there. Works in plan mode. For live site visual audits, use /design-review. Use when asked to "review the design plan" or "design critique". Proactively suggest when the user has a plan with UI/UX components that should be reviewed before implementation. (gstack)

Interactive developer experience plan review. Explores developer personas, benchmarks against competitors, designs magical moments, and traces friction points before scoring. Three modes: DX EXPANSION (competitive advantage), DX POLISH (bulletproof every touchpoint), DX TRIAGE (critical gaps only). Use when asked to "DX review", "developer experience audit", "devex review", or "API design review". Proactively suggest when the user has a plan for developer-facing products (APIs, CLIs, SDKs, libraries, platforms, docs). (gstack) Voice triggers (speech-to-text aliases): "dx review", "developer experience review", "devex review", "devex audit", "API design review", "onboarding review".

Eng manager-mode plan review. Lock in the execution plan — architecture, data flow, diagrams, edge cases, test coverage, performance. Walks through issues interactively with opinionated recommendations. Use when asked to "review the architecture", "engineering review", or "lock in the plan". Proactively suggest when the user has a plan or design doc and is about to start coding — to catch architecture issues before implementation. (gstack) Voice triggers (speech-to-text aliases): "tech review", "technical review", "plan engineering review".

Self-tuning question sensitivity + developer psychographic for gstack (v1: observational). Review which AskUserQuestion prompts fire across gstack skills, set per-question preferences (never-ask / always-ask / ask-only-for-one-way), inspect the dual-track profile (what you declared vs what your behavior suggests), and enable/disable question tuning. Conversational interface — no CLI syntax required. Use when asked to "tune questions", "stop asking me that", "too many questions", "show my profile", "what questions have I been asked", "show my vibe", "developer profile", or "turn off question tuning". (gstack) Proactively suggest when the user says the same gstack question has come up before, or when they explicitly override a recommendation for the Nth time.

Systematically QA test a web application and fix bugs found. Runs QA testing, then iteratively fixes bugs in source code, committing each fix atomically and re-verifying. Use when asked to "qa", "QA", "test this site", "find bugs", "test and fix", or "fix what's broken". Proactively suggest when the user says a feature is ready for testing or asks "does this work?". Three tiers: Quick (critical/high only), Standard (+ medium), Exhaustive (+ cosmetic). Produces before/after health scores, fix evidence, and a ship-readiness summary. For report-only mode, use /qa-only. (gstack) Voice triggers (speech-to-text aliases): "quality check", "test the app", "run QA".

Report-only QA testing. Systematically tests a web application and produces a structured report with health score, screenshots, and repro steps — but never fixes anything. Use when asked to "just report bugs", "qa report only", or "test but don't fix". For the full test-fix-verify loop, use /qa instead. Proactively suggest when the user wants a bug report without any code changes. (gstack) Voice triggers (speech-to-text aliases): "bug report", "just check for bugs".

Weekly engineering retrospective. Analyzes commit history, work patterns, and code quality metrics with persistent history and trend tracking. Team-aware: breaks down per-person contributions with praise and growth areas. Use when asked to "weekly retro", "what did we ship", or "engineering retrospective". Proactively suggest at the end of a work week or sprint. (gstack)

Pre-landing PR review. Analyzes diff against the base branch for SQL safety, LLM trust boundary violations, conditional side effects, and other structural issues. Use when asked to "review this PR", "code review", "pre-landing review", or "check my diff". Proactively suggest when the user is about to merge or land code changes. (gstack)

Import cookies from your real Chromium browser into the headless browse session. Opens an interactive picker UI where you select which cookie domains to import. Use before QA testing authenticated pages. Use when asked to "import cookies", "login to the site", or "authenticate the browser". (gstack)

Configure deployment settings for /land-and-deploy. Detects your deploy platform (Fly.io, Render, Vercel, Netlify, Heroku, GitHub Actions, custom), production URL, health check endpoints, and deploy status commands. Writes the configuration to CLAUDE.md so all future deploys are automatic. Use when: "setup deploy", "configure deployment", "set up land-and-deploy", "how do I deploy with gstack", "add deploy config".

Ship workflow: detect + merge base branch, run tests, review diff, bump VERSION, update CHANGELOG, commit, push, create PR. Use when asked to "ship", "deploy", "push to main", "create a PR", "merge and push", or "get it deployed". Proactively invoke this skill (do NOT push/PR directly) when the user says code is ready, asks about deploying, wants to push code up, or asks to create a PR. (gstack)

Clear the freeze boundary set by /freeze, allowing edits to all directories again. Use when you want to widen edit scope without ending the session. Use when asked to "unfreeze", "unlock edits", "remove freeze", or "allow all edits". (gstack)

Analyze a codebase and recommend Claude Code automations (hooks, subagents, skills, plugins, MCP servers). Use when user asks for automation recommendations, wants to optimize their Claude Code setup, mentions improving Claude Code workflows, asks how to first set up Claude Code for a project, or wants to know what Claude Code features they should use.

Audit and improve CLAUDE.md files in repositories. Use when user asks to check, audit, update, improve, or fix CLAUDE.md files. Scans for all CLAUDE.md files, evaluates quality against templates, outputs quality report, then makes targeted updates. Also use when the user mentions "CLAUDE.md maintenance" or "project memory optimization".

Solve competition math problems (IMO, Putnam, USAMO, AIME) with adversarial verification that catches the errors self-verification misses. Activates when asked to 'solve this IMO problem', 'prove this olympiad inequality', 'verify this competition proof', 'find a counterexample', 'is this proof correct', or for any problem with 'IMO', 'Putnam', 'USAMO', 'olympiad', or 'competition math' in it. Uses pure reasoning (no tools) — then a fresh-context adversarial verifier attacks the proof using specific failure patterns, not generic 'check logic'. Outputs calibrated confidence — will say 'no confident solution' rather than bluff. If LaTeX is available, produces a clean PDF after verification passes.

This skill should be used when the user asks to "build an MCP server", "create an MCP", "make an MCP integration", "wrap an API for Claude", "expose tools to Claude", "make an MCP app", or discusses building something with the Model Context Protocol. It is the entry point for MCP server development — it interrogates the user about their use case, determines the right deployment model (remote HTTP, MCPB, local stdio), picks a tool-design pattern, and hands off to specialized skills.

This skill should be used when the user wants to "package an MCP server", "bundle an MCP", "make an MCPB", "ship a local MCP server", "distribute a local MCP", discusses ".mcpb files", mentions bundling a Node or Python runtime with their MCP server, or needs an MCP server that interacts with the local filesystem, desktop apps, or OS and must be installable without the user having Node/Python set up.

Creates interactive HTML playgrounds — self-contained single-file explorers that let users configure something visually through controls, see a live preview, and copy out a prompt. Use when the user asks to make a playground, explorer, or interactive tool for a topic.

This skill should be used when the user asks to "create a plugin", "scaffold a plugin", "understand plugin structure", "organize plugin components", "set up plugin.json", "use ${CLAUDE_PLUGIN_ROOT}", "add commands/agents/skills/hooks", "configure auto-discovery", or needs guidance on plugin directory layout, manifest configuration, component organization, file naming conventions, or Claude Code plugin architecture best practices.

This skill should be used when the user asks to "add MCP server", "integrate MCP", "configure MCP in plugin", "use .mcp.json", "set up Model Context Protocol", "connect external service", mentions "${CLAUDE_PLUGIN_ROOT} with MCP", or discusses MCP server types (SSE, stdio, HTTP, WebSocket). Provides comprehensive guidance for integrating Model Context Protocol servers into Claude Code plugins for external tool and service integration.

This skill should be used when the user asks to "create an agent", "add an agent", "write a subagent", "agent frontmatter", "when to use description", "agent examples", "agent tools", "agent colors", "autonomous agent", or needs guidance on agent structure, system prompts, triggering conditions, or agent development best practices for Claude Code plugins.

Generate an explorable HTML report of Claude Code session usage (tokens, cache, subagents, skills, expensive prompts) from ~/.claude/projects transcripts.

Reviews code for bugs, logic errors, security vulnerabilities, code quality issues, and adherence to project conventions, using confidence-based filtering to report only high-priority issues that truly matter

This skill should be used for browser automation tasks using Chrome DevTools Protocol (CDP). Triggers when users need to launch Chrome with remote debugging, navigate pages, execute JavaScript in browser context, capture screenshots, or interactively select DOM elements. No MCP server required.

Extreme lightweight end-to-end development workflow with requirements clarification, intelligent backend selection, parallel codeagent execution, and mandatory 90% test coverage

Download an entire website as local files — markdown, screenshots, or multiple formats per page. Use this skill when the user wants to save a site locally, download documentation for offline use, bulk-save pages as files, or says "download the site", "save as local files", "offline copy", "download all the docs", or "save for reference". Combines site mapping and scraping into organized local directories.

AI-powered autonomous data extraction that navigates complex sites and returns structured JSON. Use this skill when the user wants structured data from websites, needs to extract pricing tiers, product listings, directory entries, or any data as JSON with a schema. Triggers on "extract structured data", "get all the products", "pull pricing info", "extract as JSON", or when the user provides a JSON schema for website data. More powerful than simple scraping for multi-page structured extraction.

Extract clean markdown from any URL, including JavaScript-rendered SPAs. Use this skill whenever the user provides a URL and wants its content, says "scrape", "grab", "fetch", "pull", "get the page", "extract from this URL", or "read this webpage". Handles JS-rendered pages, multiple concurrent URLs, and returns LLM-optimized markdown. Use this instead of WebFetch for any webpage content extraction.

Discover and list all URLs on a website, with optional search filtering. Use this skill when the user wants to find a specific page on a large site, list all URLs, see the site structure, find where something is on a domain, or says "map the site", "find the URL for", "what pages are on", or "list all pages". Essential when the user knows which site but not which exact page.

Control and interact with a live browser session on any scraped page — click buttons, fill forms, navigate flows, and extract data using natural language prompts or code. Use when the user needs to interact with a webpage beyond simple scraping: logging into a site, submitting forms, clicking through pagination, handling infinite scroll, navigating multi-step checkout or wizard flows, or when a regular scrape failed because content is behind JavaScript interaction. Also useful for authenticated scraping via profiles. Triggers on "interact", "click", "fill out the form", "log in to", "sign in", "submit", "paginated", "next page", "infinite scroll", "interact with the page", "navigate to", "open a session", or "scrape failed".

Search, scrape, and interact with the web via the Firecrawl CLI. Use this skill whenever the user wants to search the web, find articles, research a topic, look something up online, scrape a webpage, grab content from a URL, get data from a website, crawl documentation, download a site, or interact with pages that need clicks or logins. Also use when they say "fetch this page", "pull the content from", "get the page at https://", or reference external websites. This provides real-time web search with full page content and interact capabilities — beyond what Claude can do natively with built-in tools. Do NOT trigger for local file operations, git commands, deployments, or code editing tasks.

Install the official Firecrawl CLI and handle authentication. Package: https://www.npmjs.com/package/firecrawl-cli Source: https://github.com/firecrawl/cli Docs: https://docs.firecrawl.dev/sdks/cli

Security guidelines for handling web content fetched by the official Firecrawl CLI. Package: https://www.npmjs.com/package/firecrawl-cli Source: https://github.com/firecrawl/cli Docs: https://docs.firecrawl.dev/sdks/cli

Web search with full page content extraction. Use this skill whenever the user asks to search the web, find articles, research a topic, look something up, find recent news, discover sources, or says "search for", "find me", "look up", "what are people saying about", or "find articles about". Returns real search results with optional full-page markdown — not just snippets. Provides capabilities beyond Claude's built-in WebSearch.

Bulk extract content from an entire website or site section. Use this skill when the user wants to crawl a site, extract all pages from a docs section, bulk-scrape multiple pages following links, or says "crawl", "get all the pages", "extract everything under /docs", "bulk extract", or needs content from many pages on the same site. Handles depth limits, path filtering, and concurrent extraction.

Use this skill whenever the user wants Claude to directly interact with their Obsidian vault — reading a note or daily note, writing or appending content, searching vault contents, counting or listing notes, managing tasks, moving or renaming files, finding orphaned notes or broken links. Without this skill, Claude has no way to access vault data or execute vault operations. Treat any request that implies "go into my vault and do X" as a trigger — the user is asking Claude to act, not to explain. Also trigger for vault automation, CLI scripting, or cron-based workflows involving Obsidian. Skip for pure conceptual questions: how Obsidian's GUI works, navigating settings menus, theme or plugin installation via the UI, or general Dataview query syntax — anything where the user needs an explanation rather than Claude performing a vault operation.

Analyze text to detect if it was written by AI. Returns a score from 0-100 with detailed metrics. Use when checking content before publishing or submitting.

Transform AI-generated text into natural, human-like content that bypasses AI detectors like GPTZero, Turnitin, and Originality.ai. Uses credits based on word count.

Create Vue 3 components with Composition API — composables, Pinia store integration, TypeScript, and unit tests.

Build end-to-end ETL pipelines — extract from APIs/databases, transform, validate, and load into data warehouses.

Generate database migrations with up/down scripts — Alembic, Flyway, Liquibase, and framework-native migrations.

Build polished command-line tools — argument parsing, help text, interactive prompts, progress bars, and shell completions.

Transform and reshape data — pivot, melt, aggregate, join, and apply complex business rules to datasets.

Design and implement GraphQL schemas — types, queries, mutations, subscriptions, resolvers, and federation.

Build n8n automation workflows — nodes, expressions, error handling, and self-hosted deployment.

Collaborate on long-form documents — track changes, merge edits, maintain consistent voice, and manage review cycles.

Auto-generate documentation from code — docstrings, API references, README files, and changelog entries.

Perform threat modeling — STRIDE, attack trees, data flow diagrams, and mitigation recommendations.

Build apps with the Anthropic Claude API — chat completions, tool use, streaming, vision, and multi-turn conversations.

Build Chrome/Edge extensions — manifest v3, content scripts, service workers, popup UIs, and Chrome API integrations.

Design RESTful and RPC APIs — OpenAPI specs, request/response schemas, error codes, versioning, and documentation.

Perform SQL-based data analysis — exploratory queries, aggregations, funnels, cohorts, and insight narratives.

Detect hardcoded secrets and credentials in codebases — API keys, tokens, passwords, and remediation steps.

Scaffold production-ready REST APIs with authentication, rate limiting, validation, and OpenAPI docs.

Plan content calendars — themes, publishing schedules, platform mix, repurposing strategies, and campaign alignment.

Transform raw data into compelling interactive visualizations — dashboards, maps, network graphs, and Sankey diagrams.

Build Microsoft Teams apps — bots, message extensions, tabs, adaptive cards, and Graph API integration.

Build Svelte 5 components — runes, stores, SvelteKit routing, and server-side rendering.

Perform thorough code reviews — bugs, security issues, performance bottlenecks, style violations, and architectural concerns.

Write Terraform infrastructure-as-code — providers, modules, state management, and cloud resource definitions.

Create technical documentation — API docs, user guides, runbooks, architecture decision records, and onboarding guides.

Create VS Code extensions — commands, language servers, tree views, webview panels, and marketplace publishing.

Automatically fill PDF and HTML forms from structured data — applications, registrations, and government forms.

Scaffold and implement Model Context Protocol servers — tools, resources, prompts, and sampling handlers.

Automate Jira — issue creation, sprint management, JQL queries, and project reporting via REST API.

PR Automation Orchestrator: poll open PRs, check CI, run review, fix, and merge eligible PRs. Use when: (1) Invoked by daemon via scripts/pr-automation.sh, (2) User says "/pr-automation".

Use when creating a pull request, after committing changes, or when user invokes /oss-pr. Covers branch management, quality checks, commit, push, and PR creation.

Project architecture and file structure conventions for all process types. Use when: (1) Creating new files or modules, (2) Deciding where code should go, (3) Converting single-file components to directories, (4) Reviewing code for structure compliance, (5) Adding new bridges, services, agents, or workers.

Auto-fix GitHub issues labeled as bugs: fetch open bug issues, analyze feasibility, fix code, and submit PRs. One issue per invocation. Use when: (1) User says "/fix-issues", (2) User asks to fix GitHub issues.

PR Code Review (Local): perform a thorough local code review with full project context. Use when: (1) User asks to review a PR, (2) User says "/pr-review", (3) User wants to review code changes before merging.

Canonical commit workflow for Gas Town crew members: pre-flight checks, branch creation, gt commit with agent identity, push, and PR creation. Use when ready to commit and submit work for review.

List GitHub issues in a formatted ASCII table. Supports filters like --state, --assignee, --label. Use for issue triage and tracking workflows.

Run a grouped, bisectable Go dependency security sweep on the Fission repo. Use when the user asks to upgrade outdated/vulnerable Go dependencies, run a dep security pass, or process CVE findings from govulncheck. Produces one commit per logical dependency group on a dedicated branch so failures are attributable and revertable.

Perform comprehensive code reviews for TypeScript projects, analyzing type safety, best practices, performance, security, and code quality with actionable feedback

Analyze code changes and generate Playwright E2E tests in anytype-desktop-suite. Run after implementing features or modifying editor/component behavior to ensure new functionality has test coverage.

SpringBlade 通用 Git 提交工具。基于 Gitmoji 规范生成提交信息。当用户要求提交代码、commit 变更、生成 commit message、或使用 /blade-commit 时触发。默认强制简单模式（gitmoji + 一句话描述），仅当显式传入 --d 或 --detail 参数时才启用详细模式（gitmoji + conventional commit + 变更列表）。只执行 commit，绝不 push 或执行其他远程操作。确保每次提交都带有 gitmoji 图标。

SpringBlade 全栈代码生成器。根据用户提供的模块名、实体名和字段列表，自动生成符合 SpringBlade 开源版框架规范的后端代码（Boot 单体/Cloud 微服务）、前端页面（Saber Options API/Composition API）和 MySQL 建表语句。当用户说"帮我生成代码"、"创建一个新模块"、"生成 CRUD"、"新建实体"、"建表语句"、"生成前端页面"、"生成后端接口"、"生成 SpringBlade 代码"、"写一个 xxx 管理功能"、"帮我设计 xxx 表"、"blade-design"等时触发。即使用户只是描述了业务字段或给出了表结构，也应触发此技能来生成对应的 SpringBlade 规范代码。

Next.js best practices - file conventions, RSC boundaries, data patterns, async APIs, metadata, error handling, route handlers, image/font optimization, bundling

React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

Guide for building features, pages, tables, forms, themes, and navigation in this Next.js 16 shadcn dashboard template. Use this skill whenever the user wants to add a new page, create a feature module, build a data table, add a form, configure navigation items, add a theme, set up RBAC access control, or work with the dashboard's patterns and conventions. Also triggers when adding routes under /dashboard, working with Clerk auth/orgs/billing, creating mock APIs, or modifying the sidebar. Even if the user doesn't mention "dashboard" explicitly — if they're adding UI, pages, or features to this project, use this skill.

How to write and maintain `.claude/skills/*/SKILL.md` files: source-of-truth-first process, verification steps, and conventions.

Frontend standards for atopile extension webviews: architecture, contracts, design system, and testing workflow.

How the Faebryk parameter solver works (Sets/Literals, Parameters, Expressions), the core invariants enforced during mutation, and practical workflows for debugging and extending the solver. Use when implementing or modifying constraint solving, parameter bounds, or debugging expression simplification.

Generate short live progress summaries for the atopile agent from recent tool events, preambles, checklist changes, and build state. Use for ephemeral UI activity text only, never for transcript replies or autonomous reasoning.

How Faebryk's TypeGraph works (GraphView + Zig edges), how to traverse/resolve references, and how FabLL types/traits map onto edge types. Use when working with TypeGraph traversal, edge types, or building type-aware queries.

How the Zig↔Python binding layer works (pyzig), including build-on-import, wrapper generation patterns, ownership rules, and where to add new exported APIs. Use when adding Zig-Python bindings, modifying native extensions, or debugging C-API interactions.

How FabLL (faebryk.core.node) maps Python node/trait declarations into the TypeGraph + instance graph, including field/trait invariants and instantiation patterns. Use when defining new components or traits, working with the Node API, or understanding type registration.

How the Zig S-expression engine and typed KiCad models work, how they are exposed to Python (pyzig_sexp), and the invariants around parsing, formatting, and freeing. Use when working with KiCad file parsing, S-expression generation, or layout sync.

LLM-focused workflow for working in this repo: compile Zig, run the orchestrated test runner, consume test-report.json/html artifacts, and discover/debug ConfigFlags.

Write tests that verify observable behavior (contract), not implementation details. Auto-invoked when writing or reviewing tests.

GROWI testing patterns with Vitest, React Testing Library, and vitest-mock-extended.

GROWI technology stack, build tools, and global commands. Auto-invoked for all GROWI development work.

Create custom steering documents for specialized project contexts. Use when creating domain-specific steering files.

GROWI monorepo structure, workspace organization, and architectural principles. Auto-invoked for all GROWI development work.

/learn - Pattern Extraction for GROWI

AI music generation with ACE-Step 1.5 — background music, vocal tracks, covers, stem extraction, audio repainting, and continuation for video production. Use when generating music, soundtracks, jingles, or working with audio stems. Triggers include background music, soundtrack, jingle, music generation, stem extraction, cover, style transfer, repaint, continuation, or musical composition tasks.

Cloud GPU processing via RunPod serverless. Use when setting up RunPod endpoints, deploying Docker images, managing GPU resources, troubleshooting endpoint issues, or understanding costs. Covers all 5 toolkit images (qwen-edit, realesrgan, propainter, sadtalker, qwen3-tts).

Getting the duration of a video file in seconds with Mediabunny

Adaptive silence detection for video/audio files using FFmpeg loudnorm and silencedetect

Measuring DOM element dimensions in Remotion

Getting the duration of an audio file in seconds with Mediabunny

Adding AI-generated voiceover to Remotion compositions using TTS

Dynamically set composition duration, dimensions, and props

Make map animations with Mapbox

Getting the width and height of a video file with Mediabunny

AI image editing prompting patterns for Qwen-Image-Edit. Use when editing photos while preserving identity, reframing cropped images, changing clothing or accessories, adjusting poses, applying style transfers, or character transformations. Provides prompt patterns, parameter tuning, and examples.

Have a focused discussion about a topic and reach a conclusion

Audit changed code for security sharp edges — dangerous defaults, type confusion, and silent failures

AI驱动的综合健康分析系统，整合多维度健康数据、识别异常模式、预测健康风险、提供个性化建议。支持智能问答和AI健康报告生成。

Use when coordinating multiple AI agents and need to pick the right orchestration pattern - covers 10 patterns (fan-out, pipeline, hub-spoke, consensus, mesh, handoff, cascade, dag, debate, hierarchical) with decision framework and reflection protocol

Use when writing agent-relay workflows that must fully validate features end-to-end before merging. Covers the 80-to-100 pattern - going beyond "code compiles" to "feature works, tested E2E locally." Includes PGlite for in-memory Postgres testing, mock sandbox patterns, test-fix-rerun loops, verify gates after every edit, and the full lifecycle from implementation through passing tests to commit.

Use when creating new Claude Code skills or improving existing ones - ensures skills are discoverable, scannable, and effective through proper structure, CSO optimization, and real examples

Use this agent when working with prompt injection detection integration tests, including running tests, debugging failures, or adding new test samples.

Use when given a Linear issue ID, URL, identifier, or project name/URL to analyze and plan work. For issues, fetches the issue, classifies it, explores relevant code, proposes an approach, and orchestrates the right skills. For projects, fetches the project with milestones and issues, builds a prioritized execution plan, and systematically works through issues respecting project structure and dependencies.

Use when asked to review a PR, or when /review is invoked with a PR number or URL. Performs a focused code review checking for bugs, security, performance, and test gaps, then posts findings as a PR comment and formal GitHub review.

Use when modifying recce/mcp_server.py, MCP tool handlers, error classification, or MCP-related tests. Also use when adding new MCP tools or changing tool response formats.

Calculate volumes of geometric shapes for engineering design and mathematical analysis.

Query EBI GWAS Catalog for GWAS statistical associations (p-value, effect size, risk allele) between a variant and traits/diseases.

Orphan Drug & Rare Disease Analysis - Analyze orphan drugs: Monarch disease phenotypes, OpenTargets targets, FDA drug data, and clinical studies. Use this skill for orphan drug development tasks involving get joint associated diseases by HPO ID list get associated targets by disease efoId get clinical studies info by drug name pubmed search. Combines 4 tools from 4 SCP server(s).

BioSample & Genome Cross-Reference - Cross-reference biosample and genome data: NCBI biosample, genome report, sequence reports, and taxonomy. Use this skill for genomics tasks involving get biosample report get genome dataset report by accession get genome sequence reports get taxonomy. Combines 4 tools from 1 SCP server(s).

Systems Pharmacology Analysis - Systems pharmacology: drug targets, protein interactions, pathway enrichment, and gene expression. Use this skill for systems pharmacology tasks involving get target by name get string network interaction get functional enrichment get gene expression across cancers. Combines 4 tools from 3 SCP server(s).

Geometry & Trigonometry Suite - Solve geometry problems: calculate area, height from sine, angle in degrees, and increase factor. Use this skill for mathematics tasks involving calculate area calculate height from length and sine calculate phi deg calculate increase factor. Combines 4 tools from 1 SCP server(s).

Generate new peptide molecules sampling from the input peptide sequence.

Protein Interaction Network Analysis - Build protein interaction network: map identifiers with STRING, get PPI network, compute enrichment, and link to KEGG pathways. Use this skill for systems biology tasks involving mapping identifiers get string network interaction get ppi enrichment kegg link. Combines 4 tools from 2 SCP server(s).

Compute the Tanimoto similarities between a target molecule and a list of candidate molecules using Morgan fingerprints.

Nuclear Physics Calculations - Nuclear physics: energy conversion MeV to J, calculate total power, photon rate, and error analysis. Use this skill for nuclear physics tasks involving convert energy MeV to J calculate total power calculate incident photon rate calculate absolute error. Combines 4 tools from 3 SCP server(s).

Given an rsID, query multiple databases (dbSNP, FAVOR, GWAS Catalog, ClinVar, gnomAD, PharmGKB, ClinGen) for comprehensive annotation. Use when user asks a general question about a variant without specifying which aspect.

Statistical Error Analysis - Analyze measurement errors: absolute error, scientific notation, max value, mean square, and formatting. Use this skill for statistics tasks involving calculate absolute error convert to scientific notation calculate max value calculate mean square format scientific notation. Combines 5 tools from 1 SCP server(s).

Generate new molecules de novo.

Search PubMed database for scientific articles and publications to retrieve biomedical literature.

Compute the drug-likeness metrics (QED score and Number of violations of Lipinski's Rule of Five) of the input candidate molecules (SMILES format).

Calculate disease reversal scores for the provided molecules relative to a specific disease.

Cross-Species Comparative Genomics - Compare genomes across species: Ensembl compara, alignment, gene trees, and NCBI taxonomy. Use this skill for comparative genomics tasks involving get info compara species sets get alignment region get genetree member symbol get taxonomy. Combines 4 tools from 2 SCP server(s).

Pandemic Preparedness Analysis - Pandemic analysis: virus genome, taxonomy, drug candidates, and literature intelligence. Use this skill for public health tasks involving get virus dataset report get virus by taxon genome get mechanism of action by drug name tavily search search literature. Combines 5 tools from 4 SCP server(s).

Calculate peptide sequence properties including molecular weight, isoelectric point, extinction coefficient, and chemical formula.

Search biomedical literature and web content using Tavily search engine for research and clinical information.

Given a gene symbol (e.g. TPMT), query 3 public databases (ClinGen CAR, PharmGKB, Monarch) to obtain gene registry info, FDA drug labels, clinical annotations, and gene-phenotype associations. Save all results into a JSON file.

Search for similar molecules using Tanimoto similarity with Morgan fingerprints to identify structurally related compounds.

Ring System Analysis - Analyze ring systems: count aliphatic carbocycles, analyze aromaticity, compute topology, and structure complexity. Use this skill for organic chemistry tasks involving GetAliphaticCarbocyclesNum AromaticityAnalyzer calculate mol topology calculate mol structure complexity. Combines 4 tools from 3 SCP server(s).

Structural Homology & Evolution Analysis - Analyze protein evolution: get gene tree from Ensembl, find homologs, compare sequences, and predict structure. Use this skill for evolutionary biology tasks involving get homology symbol get genetree member symbol calculate protein sequence properties pred protein structure esmfold. Combines 4 tools from 3 SCP server(s).

Predict protein-ligand binding affinity using Boltz-2 model to assess molecular interactions and binding probability for drug discovery.

Search the protein information from the input gene name and downloads the optimal PDB or AlphaFold structures.

Drug Metabolism Study - Study drug metabolism: FDA metabolism data, ChEMBL metabolism records, PubChem compound data, and clinical pharmacology. Use this skill for drug metabolism tasks involving get metabolism by id get pharmacokinetics by drug name get compound by name get clinical pharmacology by drug name. Combines 4 tools from 3 SCP server(s).

UCSC Genome Browser Exploration - Explore genome via UCSC: list genomes, list tracks, get sequence, get track data, and cytoband info. Use this skill for genomics tasks involving list genomes list tracks get sequence get track data get cytoband. Combines 5 tools from 1 SCP server(s).

Electromagnetic Field Analysis - Analyze EM fields: vacuum permittivity, total charge, radiation pressure, and photon calculations. Use this skill for electromagnetics tasks involving calculate vacuum permittivity calculate total charge calculate radiation pressure calculate total power. Combines 4 tools from 2 SCP server(s).

Alanine Scanning Mutagenesis Pipeline - Alanine scanning: design scan, compute properties for each mutant, predict interactions, and compare. Use this skill for protein biochemistry tasks involving AlanineScanningDesigner ComputeProtPara PredictDrugTargetInteraction calculate protein sequence properties. Combines 4 tools from 3 SCP server(s).

Calculate comprehensive protein sequence properties including isoelectric point, molecular weight, hydrophobicity, and physicochemical parameters.

Multi-Species Gene Analysis - Analyze gene across species: Ensembl homologs, NCBI orthologs, cross-species STRING similarity, and taxonomy. Use this skill for comparative genomics tasks involving get homology symbol get gene orthologs get best similarity hits between species get taxonomy. Combines 4 tools from 3 SCP server(s).

Combinatorial Chemistry Library Design - Design combinatorial library: validate core SMILES, generate variants, compute properties, and predict ADMET for library. Use this skill for combinatorial chemistry tasks involving is valid smiles calculate mol basic info calculate mol drug chemistry pred molecule admet. Combines 4 tools from 2 SCP server(s).

Comprehensive protein analysis combining InterProScan domain identification with BLAST similarity search to provide complete functional and evolutionary annotation.

Gene-Disease Association Analysis - Analyze gene-disease associations: NCBI gene metadata, OpenTargets disease associations, TCGA expression, and Monarch phenotypes. Use this skill for medical genetics tasks involving get gene metadata by gene name get associated targets by disease efoId get gene expression across cancers get joint associated diseases by HPO ID list. Combines 4 tools from 4 SCP server(s).

Protein Classification Analysis - Classify protein: ChEMBL protein classification, UniProt entry, InterPro domains, and Ensembl biotypes. Use this skill for protein science tasks involving search protein classification get uniprotkb entry by accession query interpro get info biotypes. Combines 4 tools from 4 SCP server(s).

Genetic Counseling Variant Report - Generate variant report for genetic counseling: VEP, ClinVar, gene phenotype, and literature evidence. Use this skill for clinical genetics tasks involving get vep hgvs clinvar search get phenotype gene pubmed search. Combines 4 tools from 2 SCP server(s).

Functional Group Profiling - Profile functional groups: radical assignment, H-bond analysis, aromaticity, and abbreviation condensation. Use this skill for organic chemistry tasks involving AssignRadicals GetHBANum AromaticityAnalyzer CondenseAbbreviationSubstanceGroups. Combines 4 tools from 2 SCP server(s).

Drug Target Identification Pipeline - Identify drug targets for a disease by querying OpenTargets for associated targets, then retrieve detailed target info from ChEMBL and protein data from UniProt. Use this skill for drug discovery tasks involving get associated targets by disease efoId get target by name get general info by protein or gene name. Combines 3 tools from 3 SCP server(s).

Comparative Drug Analysis - Compare drugs: structure analysis, PubChem data, FDA safety, and ChEMBL bioactivity. Use this skill for comparative pharmacology tasks involving ChemicalStructureAnalyzer get compound by name get adverse reactions by drug name search activity. Combines 4 tools from 4 SCP server(s).

Experimental Data Processing - Process experimental data: absolute error, mean square, max value, scientific notation formatting. Use this skill for experimental physics tasks involving calculate absolute error calculate mean square calculate max value format scientific notation convert to scientific notation. Combines 5 tools from 1 SCP server(s).

Retrieve gene information from NCBI Gene database by gene IDs to obtain genomic details, function, and expression data.

Chemical Structure Comparison - Compare chemical structures: get SMILES, analyze structures, compute similarity, and check PubChem records. Use this skill for cheminformatics tasks involving NameToSMILES ChemicalStructureAnalyzer calculate smiles similarity get compound by name. Combines 4 tools from 4 SCP server(s).

Gene Therapy Target Analysis - Analyze gene therapy target: gene info, variant pathogenicity, protein structure, and clinical evidence. Use this skill for gene therapy tasks involving get gene metadata by gene name get vep hgvs Protein structure prediction ESMFold clinvar search. Combines 4 tools from 4 SCP server(s).

Genome Annotation Pipeline - Annotate a genome: NCBI annotation report, Ensembl gene lookup, UCSC tracks, and KEGG pathway links. Use this skill for genomics tasks involving get genome annotation report get lookup symbol list tracks kegg link. Combines 4 tools from 4 SCP server(s).

Retrieve SMILES strings from PubChem using compound names.

Protein-Drug Interaction Profiling - Profile protein-drug interactions: protein properties, drug structure, binding affinity prediction, and interaction data. Use this skill for molecular pharmacology tasks involving calculate protein sequence properties ChemicalStructureAnalyzer boltz binding affinity PredictDrugTargetInteraction. Combines 4 tools from 4 SCP server(s).

Charge Carrier Mobility Analysis - Analyze carrier mobility: calculate new mobility, compute vacuum permittivity, and error analysis. Use this skill for semiconductor physics tasks involving calculate new mobility calculate vacuum permittivity calculate absolute error calculate mean square. Combines 4 tools from 2 SCP server(s).

Energy Unit Conversion Pipeline - Convert between energy units and analyze: MeV to Joules, scientific notation, and error calculation. Use this skill for physics tasks involving convert energy MeV to J convert to scientific notation format scientific notation calculate absolute error. Combines 4 tools from 2 SCP server(s).

Calculate sound speed in seawater from practical salinity, temperature, and pressure using the Gibbs Seawater Oceanographic Toolbox.

Assess drug risks and adverse effects using FDA drug database to retrieve safety information and risk profiles.

SNP Functional Impact Analysis - Analyze SNP function: VEP prediction, variation details, phenotype association, and literature evidence. Use this skill for functional genomics tasks involving get vep id get variation get phenotype accession pubmed search. Combines 4 tools from 2 SCP server(s).

Protein Engineering Workflow - Engineer a protein: predict structure, identify functional residues, predict beneficial mutations, and calculate properties. Use this skill for protein engineering tasks involving Protein structure prediction ESMFold predict functional residue zero shot sequence prediction calculate protein sequence properties. Combines 4 tools from 2 SCP server(s).

Perform meta-analysis on scientific studies to synthesize research findings and generate comprehensive reports with statistical summaries.

Thermal & Heat Transfer Analysis - Analyze thermal system: calculate heat released, convert energy units, compute potential energy, and dynamic viscosity. Use this skill for thermal engineering tasks involving calculate heat released convert energy MeV to J calculate potential energy calculate dynamic viscosity. Combines 4 tools from 1 SCP server(s).

Search PubChem database using SMILES strings to retrieve compound information and chemical properties.

Retrieve phenotype information from Monarch Initiative using HPO (Human Phenotype Ontology) IDs to understand disease manifestations.

Bioassay Data Analysis - Analyze bioassay data: PubChem assay summary, ChEMBL activity search, compound properties, and target info. Use this skill for bioassay science tasks involving get assay summary by cid search activity calculate mol basic info get target by name. Combines 4 tools from 3 SCP server(s).

Generate new molecules sampling from the input scaffold.

Precision Oncology Workflow - Precision oncology: tumor expression profiling, variant analysis, targeted therapy lookup, and clinical trials. Use this skill for precision oncology tasks involving get gene expression across cancers get vep hgvs get associated drugs by target name get clinical studies info by drug name pubmed search. Combines 5 tools from 5 SCP server(s).

Scientific Literature Mining - Mine scientific literature: PubMed search, arXiv search, web search, and Tavily deep search. Use this skill for scientific informatics tasks involving pubmed search search literature search web tavily search. Combines 4 tools from 2 SCP server(s).

Convert SMILES strings to CAS registry numbers using material informatics tools to identify chemical substances.

Protein Complex Visualization & Analysis - Analyze protein complex: download structure, visualize complex, extract chains, and calculate quality metrics. Use this skill for structural biology tasks involving retrieve protein data by pdbcode visualize complex extract pdb chains calculate pdb basic info. Combines 4 tools from 1 SCP server(s).

Disease-Drug Landscape Analysis - Map the drug landscape for a disease: OpenTargets disease drugs, FDA indications, and clinical studies. Use this skill for drug discovery tasks involving get associated drugs by target name get drug names by indication get clinical studies info by drug name. Combines 3 tools from 2 SCP server(s).

Search scientific literature and research papers using FlowSearch to find relevant academic articles and publications.

AlphaFold Structure Analysis Pipeline - AlphaFold pipeline: download predicted structure, predict pockets, extract sequence, and compute properties. Use this skill for computational biology tasks involving download alphafold structure run fpocket extract pdb sequence calculate pdb basic info. Combines 4 tools from 3 SCP server(s).

Drug Repurposing Screening - Screen existing drugs for new indications by querying FDA indications, ChEMBL mechanisms, and OpenTargets drug-disease associations. Use this skill for drug discovery tasks involving get indications by drug name get mechanism of action by drug name get drug by name get associated drugs by target name. Combines 4 tools from 3 SCP server(s).

Pharmacogenomics Analysis - Pharmacogenomics analysis: FDA pharmacogenomics info, variant effects, ClinVar pathogenicity, and gene expression. Use this skill for pharmacogenomics tasks involving get pharmacogenomics info by drug name get vep hgvs clinvar search get gene expression across cancers. Combines 4 tools from 4 SCP server(s).

Calculate basic molecular properties from SMILES including molecular weight, formula, atom counts, and exact mass.

Pharmacokinetics Profile Builder - Build a PK profile: FDA pharmacokinetics, clinical pharmacology, dosage info, and molecular properties. Use this skill for pharmacology tasks involving get pharmacokinetics by drug name get clinical pharmacology by drug name get dosage and storage information by drug name get compound by name. Combines 4 tools from 2 SCP server(s).

Molecular Fingerprint Analysis - Fingerprint analysis: topology descriptors, structure complexity, similarity calculation, and AromaticityAnalysis. Use this skill for cheminformatics tasks involving calculate mol topology calculate mol structure complexity calculate smiles similarity AromaticityAnalyzer. Combines 4 tools from 2 SCP server(s).

Disease Protein Profiling - Profile a disease protein: UniProt data, AlphaFold structure, InterPro domains, phenotype associations from Ensembl. Use this skill for medical proteomics tasks involving query uniprot download alphafold structure query interpro get phenotype gene. Combines 4 tools from 2 SCP server(s).

Gene-Variant-Drug Nexus - Connect gene variants to drugs: variant effect, gene-disease link, drug associations, and clinical evidence. Use this skill for translational genomics tasks involving get vep hgvs get associated targets by disease efoId get associated drugs by target name clinvar search. Combines 4 tools from 3 SCP server(s).

SMILES Comprehensive Analysis - Comprehensive SMILES analysis: validate, convert name, compute all molecular descriptors, and predict ADMET. Use this skill for cheminformatics tasks involving is valid smiles ChemicalStructureAnalyzer calculate mol basic info pred molecule admet. Combines 4 tools from 3 SCP server(s).

One Health Pathogen Analysis - One Health analysis: pathogen genome, cross-species gene comparison, antimicrobial drugs, and environmental context. Use this skill for one health tasks involving get genome dataset report by taxon get homology symbol get mechanism of action by drug name tavily search get taxonomy. Combines 5 tools from 4 SCP server(s).

Check if the input protein sequence or molecule SMILES string is valid.

Enzyme Inhibitor Design - Design enzyme inhibitor: target structure, pocket prediction, compound screening, and ADMET assessment. Use this skill for enzyme pharmacology tasks involving retrieve protein data by pdbcode pred pocket prank quick molecule docking pred molecule admet calculate mol drug chemistry. Combines 5 tools from 2 SCP server(s).

Chemical Safety Assessment - Assess chemical safety: PubChem compound info, FDA drug data, ADMET prediction, and structural alerts from ChEMBL. Use this skill for chemical safety tasks involving get general info by compound name get warnings and cautions by drug name pred molecule admet get compound structural alert. Combines 4 tools from 4 SCP server(s).

Convert between molecular formats including SMILES, InChI, InChIKey, and SELFIES for cheminformatics applications.

Epigenetics & Drug Response - Link epigenetics to drug response: gene regulation, variant effects, drug interactions, and expression. Use this skill for epigenetic pharmacology tasks involving get overlap region get vep hgvs get drug interactions by drug name get gene expression across cancers. Combines 4 tools from 3 SCP server(s).

Multi-Omics Integration - Integrate multi-omics: gene expression, protein data, pathway enrichment, and metabolic pathways. Use this skill for multi-omics tasks involving get gene expression across cancers get uniprotkb entry by accession get functional enrichment kegg get. Combines 4 tools from 4 SCP server(s).

Drug Toxicity Assessment - Comprehensive toxicity assessment: FDA adverse reactions, nonclinical toxicology, carcinogenicity data, and ADMET prediction. Use this skill for toxicology tasks involving get adverse reactions by drug name get nonclinical toxicology info by drug name get carcinogenic mutagenic fertility impairment info by drug name pred molecule admet. Combines 4 tools from 2 SCP server(s).

Rare Disease Genetic Analysis - Analyze rare disease genetics: Monarch phenotype-disease mapping, ClinVar variants, NCBI gene data, and OpenTargets. Use this skill for rare disease genetics tasks involving get HPO ID by phenotype get joint associated diseases by HPO ID list clinvar search get associated targets by disease efoId. Combines 4 tools from 3 SCP server(s).

Infectious Disease Analysis - Analyze infectious disease: virus data, taxonomy, antimicrobial drugs, and resistance literature. Use this skill for infectious disease tasks involving get virus dataset report get taxonomy get mechanism of action by drug name pubmed search. Combines 4 tools from 3 SCP server(s).

Metabolomics Pathway Analysis - Analyze metabolomics: compound identification, KEGG pathway mapping, enzyme links, and PubChem data. Use this skill for metabolomics tasks involving search pubchem by name kegg find kegg link kegg get. Combines 4 tools from 2 SCP server(s).

Drug Warning Intelligence Report - Generate drug warning report: ChEMBL drug warnings, FDA boxed warnings, adverse reactions, and environmental warnings. Use this skill for pharmacovigilance tasks involving get drug warning by id get boxed warning info by drug name get adverse reactions by drug name get environmental warning by drug name. Combines 4 tools from 2 SCP server(s).

Gene Comprehensive Lookup - Comprehensive gene lookup: NCBI gene data, Ensembl gene info, UniProt protein data, and KEGG pathway links. Use this skill for bioinformatics tasks involving get gene metadata by gene name get lookup symbol get general info by protein or gene name kegg find. Combines 4 tools from 4 SCP server(s).

Calculate atmospheric parameters including Coriolis parameter, geostrophic wind, heat index, potential temperature, and dewpoint for meteorology and climate science.

CAS Number Compound Lookup - Look up compounds by CAS: convert CAS to price/availability, get PubChem data, get ChEMBL info, and structure analysis. Use this skill for chemical information tasks involving CASToPrice get compound by name get molecule by name ChemicalStructureAnalyzer. Combines 4 tools from 4 SCP server(s).

Convert physical quantities and units at nanoscale for materials science and nanotechnology applications.

Query dbSNP + NCBI Gene to get variant genomic position (chromosome, coordinates, ref/alt alleles, mutation type) and associated gene coordinates.

UniProt Deep Protein Analysis - Deep UniProt analysis: entry data, UniRef clusters, UniParc cross-references, and gene-centric view. Use this skill for protein science tasks involving get uniprotkb entry by accession get uniref cluster by id get uniparc entry by upi get gene centric by accession. Combines 4 tools from 1 SCP server(s).

Assess wind energy potential and perform site analysis using atmospheric science calculations.

Protein Structure Quality Assessment - Assess structure quality: basic info, geometry analysis, quality metrics, composition, and visualization. Use this skill for structural biology tasks involving calculate pdb basic info calculate pdb structural geometry calculate pdb quality metrics calculate pdb composition info visualize protein. Combines 5 tools from 1 SCP server(s).

Cross-Species Protein Comparison - Compare proteins across species: get orthologs from NCBI, compute properties for each, and compare similarity. Use this skill for comparative biology tasks involving get gene orthologs calculate protein sequence properties calculate smiles similarity get homology id. Combines 4 tools from 3 SCP server(s).

Use ESMFold model to predict 3D structure of the input protein sequence.

Analyze protein sequences using InterProScan to identify functional domains, protein families, and Gene Ontology (GO) annotations.

Antibody Drug Development - Develop antibody drug: target protein analysis, biotherapeutic lookup, protein properties, and interaction prediction. Use this skill for biologics tasks involving get uniprotkb entry by accession get biotherapeutic by name ComputeProtPara ComputeHydrophilicity. Combines 4 tools from 3 SCP server(s).

Calculate the freezing point temperature of seawater from absolute salinity and pressure using GSW thermodynamic equations.

Transcriptome Analysis Pipeline - Analyze transcriptome: Ensembl transcript lookup, sequence retrieval, haplotype analysis, and UCSC track data. Use this skill for transcriptomics tasks involving get lookup id get sequence id get transcript haplotypes get track data. Combines 4 tools from 2 SCP server(s).

Analyze DNA and RNA sequences including molecular weight calculation, reverse complement generation, and oligonucleotide properties.

NCBI Gene Deep Dive - Deep dive into NCBI gene: metadata, dataset report, product report, orthologs, and gene links. Use this skill for gene biology tasks involving get gene metadata by gene name get gene dataset report by id get gene product report by id get gene orthologs get gene links by id. Combines 5 tools from 1 SCP server(s).

Substance Toxicology Report - Toxicology report: PubChem substance data, FDA toxicology, carcinogenicity data, and environmental warnings. Use this skill for toxicology tasks involving get substance by name get nonclinical toxicology info by drug name get carcinogenic mutagenic fertility impairment info by drug name get environmental warning by drug name. Combines 4 tools from 2 SCP server(s).

Antibody-Target Analysis - Analyze an antibody target: UniProt protein info, InterPro domains, protein properties, and biotherapeutic data from ChEMBL. Use this skill for immunology tasks involving get uniprotkb entry by accession query interpro ComputeProtPara get biotherapeutic by name. Combines 4 tools from 4 SCP server(s).

Search ChEMBL database for molecule information by name to retrieve bioactivity data and chemical structures.

Comprehensive molecular property analysis covering basic info, hydrophobicity, H-bonding, structural complexity, topology, drug-likeness, charge distribution, and complexity metrics.

Chemical Property Profiling - Profile chemical properties: basic info, hydrophobicity, H-bonds, charges, and molecular complexity. Use this skill for physical chemistry tasks involving calculate mol basic info calculate mol hydrophobicity calculate mol hbond calculate mol charge calculate mol complexity. Combines 5 tools from 1 SCP server(s).

Proteome-Level Analysis - Analyze at proteome level: get proteome from UniProt, gene-centric view, functional annotation from STRING. Use this skill for proteomics tasks involving get proteome by id get gene centric by proteome get functional annotation. Combines 3 tools from 2 SCP server(s).

Tissue-Specific Expression Analysis - Analyze tissue-specific expression: ChEMBL tissue data, TCGA cancer expression, Ensembl gene info, and NCBI gene data. Use this skill for tissue biology tasks involving get tissue by id get gene expression across cancers get lookup symbol get gene metadata by gene name. Combines 4 tools from 4 SCP server(s).

Query IGVF Catalog for regulatory element–gene associations within a genomic region, including association scores, element types, and biosample context.

Epigenomic Landscape Mapping - Map epigenomic landscape: overlapping features, regulatory elements, binding matrices, and phenotype links. Use this skill for epigenomics tasks involving get overlap region get phenotype region get species binding matrix get track data. Combines 4 tools from 2 SCP server(s).

Structural Pharmacogenomics - Link structure to pharmacogenomics: variant effect, protein structure change, drug binding, and clinical data. Use this skill for pharmacogenomics tasks involving get vep hgvs pred protein structure esmfold boltz binding affinity get pharmacogenomics info by drug name. Combines 4 tools from 3 SCP server(s).

Predict a molecule's ability to reverse disease states using DLEPS (Disease-Ligand Embedding Projection Score) for drug repositioning and discovery.

Affinity Maturation Pipeline - Affinity maturation: compute binding affinity, predict mutations, compute hydrophilicity, and predict drug-target interaction. Use this skill for antibody engineering tasks involving ComputeAffinityCalculator zero shot sequence prediction ComputeHydrophilicity PredictDrugTargetInteraction. Combines 4 tools from 3 SCP server(s).

ADMET & Drug-Likeness Report - Generate comprehensive ADMET and drug-likeness report: molecular properties, H-bond analysis, hydrophobicity, topology, and ADMET prediction. Use this skill for medicinal chemistry tasks involving calculate mol basic info calculate mol hbond calculate mol hydrophobicity calculate mol topology pred molecule admet. Combines 5 tools from 2 SCP server(s).

Disease Knowledge Graph - Build disease knowledge graph: OpenTargets targets, drugs, publications, and phenotypes. Use this skill for disease informatics tasks involving get associated targets by disease efoId get associated drugs by target name get publications by drug name get associated phenotypes by disease efoId. Combines 4 tools from 1 SCP server(s).

Predict the ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties of the input molecules.

Comprehensive drug screening pipeline from molecular filtering through QED/ADMET criteria to protein-ligand docking, identifying promising drug candidates.

Enzyme Active Site Engineering - Engineer enzyme: identify active site residues, predict pocket, analyze binding site, and predict mutations. Use this skill for enzymology tasks involving predict functional residue run fpocket get binding site by id pred mutant sequence. Combines 4 tools from 3 SCP server(s).

Gene Ontology Analysis - Analyze GO terms: ChEMBL GO slim, STRING functional enrichment, STRING annotation, and Ensembl ontology. Use this skill for functional genomics tasks involving get go slim by id get functional enrichment get functional annotation get ontology name. Combines 4 tools from 3 SCP server(s).

Analyze chemical structures from compound names to retrieve SMILES, molecular formulas, molecular weight, and LogP values.

Retrieve disease-associated targets from Open Targets using disease EFO IDs to identify therapeutic targets.

Personalized Medicine Report - Generate personalized medicine report: pharmacogenomics, variant effects, drug safety, and clinical pharmacology. Use this skill for precision medicine tasks involving get pharmacogenomics info by drug name get vep hgvs get adverse reactions by drug name get clinical pharmacology by drug name. Combines 4 tools from 2 SCP server(s).

Drug-Drug Interaction Checker - Check interactions between multiple drugs using FDA interaction data, PubChem compound info, and ChEMBL target overlap analysis. Use this skill for clinical pharmacology tasks involving get drug interactions by drug name get compound by name get target by name. Combines 3 tools from 3 SCP server(s).

Polymer & Material Property Analysis - Analyze polymer properties: composition, symmetry, density, and lattice parameters for material design. Use this skill for polymer science tasks involving MaterialCompositionAnalyzer CalculateSymmetry CalculateDensity MofLattice. Combines 4 tools from 2 SCP server(s).

Cross-Database Compound Lookup - Cross-reference compound across databases: PubChem, ChEMBL, KEGG, and CAS number lookup. Use this skill for chemical information tasks involving get compound by name get molecule by name kegg find CASToPrice. Combines 4 tools from 4 SCP server(s).

Virtual Screening Pipeline - Virtual screening: search PubChem by substructure, compute similarity, filter by drug-likeness, and predict binding affinity. Use this skill for drug discovery tasks involving search pubchem by smiles calculate smiles similarity calculate mol drug chemistry boltz binding affinity. Combines 4 tools from 3 SCP server(s).

Retrieve protein sequences and functional information from UniProt database by protein name, enabling protein analysis and bioinformatics workflows.

Molecular Visualization Suite - Visualize molecules: convert SMILES to formats, visualize molecule, visualize protein, visualize complex. Use this skill for chemical visualization tasks involving convert smiles to format visualize molecule visualize protein visualize complex. Combines 4 tools from 1 SCP server(s).

Clinical Pharmacology Report - Generate clinical pharmacology report: PK, PD, mechanism, drug interactions, and special populations. Use this skill for clinical pharmacology tasks involving get pharmacokinetics by drug name get pharmacodynamics by drug name get mechanism of action by drug name get drug interactions by drug name get geriatric use info by drug name. Combines 5 tools from 1 SCP server(s).

Calculate electrical capacitance from geometric parameters and dielectric properties for circuit design.

Multi-Unit Conversion Suite - Convert units across domains: length mm to m, radius m to cm, dimensions to meters, nm to um, volume to cm3. Use this skill for metrology tasks involving convert length mm to m convert radius m to cm convert dimensions to meters convert nm to um convert volume to cm3. Combines 5 tools from 1 SCP server(s).

Variant Pathogenicity Assessment - Assess variant pathogenicity: Ensembl VEP prediction, ClinVar lookup, variation details, and gene phenotype associations. Use this skill for clinical genetics tasks involving get vep hgvs clinvar search get variation get phenotype gene. Combines 4 tools from 2 SCP server(s).

Chemical Patent & Novelty Analysis - Analyze chemical novelty: PubChem substructure CAS search, ChEMBL similarity search, compound synonyms, and literature. Use this skill for patent chemistry tasks involving get substructure cas get similarity by smiles get compound synonyms by name search literature. Combines 4 tools from 3 SCP server(s).

Disease-Specific Compound Screening - Screen compounds for disease: get DLEPS score for disease relevance, predict ADMET, and check drug-likeness. Use this skill for drug discovery tasks involving calculate dleps score pred molecule admet calculate mol drug chemistry get compound by name. Combines 4 tools from 3 SCP server(s).

Query FAVOR API for variant functional prediction scores (CADD, SIFT, PolyPhen, REVEL, etc.) and gene annotation.

Regulatory Region Analysis - Analyze regulatory regions: get overlapping features, binding matrix, sequence, and phenotype associations. Use this skill for epigenomics tasks involving get overlap region get species binding matrix get sequence get phenotype region. Combines 4 tools from 2 SCP server(s).

Retrieve gene expression data from TCGA (The Cancer Genome Atlas) to analyze cancer-specific expression patterns.

Cell Line Assay Analysis - Analyze cell line assays: ChEMBL cell line info, assay search, activity data, and target info. Use this skill for cell biology tasks involving get cell line by id search assay search activity get target by name. Combines 4 tools from 1 SCP server(s).

Length & Dimension Measurement - Precision length measurement: convert mm to m, calculate length plus width, area, and error. Use this skill for metrology tasks involving convert length mm to m calculate length plus width calculate area calculate absolute error. Combines 4 tools from 3 SCP server(s).

Cancer Therapy Design - Design cancer therapy: identify targets, find drugs, check safety, and analyze differential expression. Use this skill for oncology tasks involving get associated targets by disease efoId get associated drugs by target name get adverse reactions by drug name tcga differential expression analysis. Combines 4 tools from 3 SCP server(s).

Retrieve SMILES strings from PubChem database using compound names to obtain molecular structures from common chemical names.

Organism Classification & Database - Classify organism: NCBI taxonomy, Ensembl taxonomy, ChEMBL organisms, and genome info. Use this skill for taxonomy tasks involving get taxonomy get taxonomy id get organism by id get genome dataset report by taxon. Combines 4 tools from 3 SCP server(s).

Protein Solubility Optimization - Optimize protein solubility: calculate properties, predict solubility, predict hydrophilicity, and suggest mutations. Use this skill for protein engineering tasks involving calculate protein sequence properties predict protein function ComputeHydrophilicity zero shot sequence prediction. Combines 4 tools from 3 SCP server(s).

Pediatric Drug Safety Review - Evaluate pediatric drug safety: pediatric use info, child safety, dosage forms, and overdosage info from FDA. Use this skill for pediatric pharmacology tasks involving get pediatric use info by drug name get child safety info by drug name get dosage forms and strengths by drug name get overdosage info by drug name. Combines 4 tools from 1 SCP server(s).

Full Protein Characterization - Complete protein characterization: validate sequence, compute all properties, predict structure, and analyze pockets. Use this skill for protein biochemistry tasks involving is valid protein sequence analyze protein ComputeProtPara pred protein structure esmfold run fpocket. Combines 5 tools from 4 SCP server(s).

Protein Similarity Search - Search for similar proteins: extract sequence from PDB, search structures with FoldSeek, find homologs with STRING, and check UniProt. Use this skill for bioinformatics tasks involving extract pdb sequence foldseek search get best similarity hits between species search uniprotkb entries. Combines 4 tools from 3 SCP server(s).

Compound-to-Drug Analysis Pipeline - Full compound-to-drug pipeline: name-to-SMILES conversion, structure analysis, drug-likeness, and FDA drug lookup. Use this skill for drug development tasks involving NameToSMILES ChemicalStructureAnalyzer calculate mol drug chemistry get drug by name. Combines 4 tools from 4 SCP server(s).

Retrieve genomic sequences from Ensembl database using transcript or gene IDs to obtain nucleotide and protein sequences.

ATC Drug Classification Lookup - Look up drug in ATC classification: ChEMBL ATC class, FDA drug info, PubChem compound, and mechanism of action. Use this skill for pharmacology tasks involving get atc class by level5 get mechanism of action by drug name get compound by name get drug by name. Combines 4 tools from 3 SCP server(s).

Gene Family Evolution Analysis - Analyze gene family evolution: CAFE gene tree, homology, Ensembl gene tree, and taxonomy. Use this skill for molecular evolution tasks involving get cafe genetree member symbol get homology symbol get genetree member symbol get taxonomy classification. Combines 4 tools from 1 SCP server(s).

Protein Structure Comprehensive Analysis - Comprehensive structure analysis: download PDB, extract chains, calculate geometry, quality metrics, and composition. Use this skill for structural biology tasks involving retrieve protein data by pdbcode extract pdb chains calculate pdb structural geometry calculate pdb quality metrics calculate pdb composition info. Combines 5 tools from 1 SCP server(s).

Implement data transmission between the local computer and the MCP Server using Base64 encoding

Calculate advanced molecular descriptors including shape indices, connectivity indices, and structural features for QSAR and drug discovery.

Electrical Circuit Analysis - Analyze electrical circuit: compute capacitance, convert resistance units, calculate total charge, and duty cycle. Use this skill for electrical engineering tasks involving convert resistance kOhm to Ohm calculate geometric term calculate absolute error. Combines 3 tools from 3 SCP server(s).

Protein Function Annotation Pipeline - Annotate protein function: UniProt metadata, InterPro domains, functional prediction, and GO enrichment. Use this skill for proteomics tasks involving query uniprot query interpro predict protein function get functional enrichment. Combines 4 tools from 2 SCP server(s).

Process seismic waveform data including reading MinISEED/SAC files, extracting metadata, and visualizing earthquake signals.

InterProScan Analysis Pipeline - Run InterProScan for domain analysis, then enrich with UniProt data and STRING interactions. Use this skill for functional proteomics tasks involving interproscan analyze get uniprotkb entry by accession get functional enrichment query interpro. Combines 4 tools from 4 SCP server(s).

Calculate mass percentages and stoichiometric ratios for chemical reactions and compound compositions.

Query NCBI ClinVar for variant clinical pathogenicity classification (Pathogenic/Benign/VUS), review status and associated diseases.

Query gnomAD for variant allele frequency across populations. Uses FAVOR to convert rsID→variant_id first, then queries gnomAD.

Clinical Trial Drug Profiling - Profile drug for clinical trials: FDA clinical studies, contraindications, pregnancy info, and geriatric use. Use this skill for clinical research tasks involving get clinical studies info by drug name get contraindications by drug name get pregnancy effects info by drug name get geriatric use info by drug name. Combines 4 tools from 1 SCP server(s).

Search for similar protein sequences in UniProt Swiss-Prot database using BLAST to identify homologous proteins and functional relationships.

Mouse Model Disease Analysis - Analyze mouse disease models: MouseMine search, NCBI mouse gene data, Ensembl cross-species comparison, and orthologs. Use this skill for model organisms tasks involving mousemine search get gene metadata by gene name get homology symbol get gene orthologs. Combines 4 tools from 3 SCP server(s).

Generate detailed laboratory protocols from natural language descriptions using AI, producing step-by-step experimental procedures ready for lab execution.

Drug-Target Structural Biology - Integrate drug and target structure: get drug from ChEMBL, target structure from PDB, dock them, and predict ADMET. Use this skill for structural pharmacology tasks involving get drug by name retrieve protein data by pdbcode quick molecule docking pred molecule admet. Combines 4 tools from 3 SCP server(s).

Lab Protocol from Literature - Extract and generate lab protocol: search PubMed, extract protocol from paper, and generate executable protocol. Use this skill for lab science tasks involving pubmed search extract protocol from pdf protocol generation generate executable json. Combines 4 tools from 2 SCP server(s).

Generate new molecules sampling from the input two warhead fragments.

PubChem Deep Dive Analysis - Deep dive into PubChem: compound info, bioassay summary, 3D conformers, synonyms, and general description. Use this skill for chemical databases tasks involving get pubchem compound by cid get assay summary by cid get conformers by cid get compound synonyms by name get general info by compound name. Combines 5 tools from 1 SCP server(s).

Microbiome Genomics Analysis - Analyze microbial genome: NCBI genome data, taxonomy, KEGG metabolic pathways, and annotation. Use this skill for metagenomics tasks involving get genome dataset report by taxon get taxonomy kegg find get genome annotation report. Combines 4 tools from 2 SCP server(s).

Convert laboratory protocols to executable JSON format using Thoth-OP for automated lab equipment control.

BLAST & Protein Analysis Pipeline - BLAST search followed by comprehensive protein analysis: BLAST, then structure prediction, properties, and function. Use this skill for sequence bioinformatics tasks involving blast search pred protein structure esmfold calculate protein sequence properties predict protein function. Combines 4 tools from 4 SCP server(s).

Query PharmGKB (clinPGx) for pharmacogenomic clinical annotations — how a variant affects drug response, dosing, and adverse reactions.

Drug-Indication Mapping - Map drug indications: ChEMBL drug indications, FDA indications, OpenTargets drug associations, and literature. Use this skill for clinical informatics tasks involving get drug indication by id get indications by drug name get associated drugs by target name pubmed search. Combines 4 tools from 4 SCP server(s).

Gene Expression Atlas - Build gene expression atlas: TCGA cancer expression, NCBI gene info, Ensembl gene details, and literature search. Use this skill for transcriptomics tasks involving get gene expression across cancers get gene metadata by gene name get lookup symbol search literature. Combines 4 tools from 4 SCP server(s).

Gene-to-Drug Discovery Pipeline - Full gene-to-drug pipeline: gene lookup, protein structure, binding pocket, virtual screening, and drug-likeness. Use this skill for translational medicine tasks involving get gene metadata by gene name pred protein structure esmfold run fpocket boltz binding affinity calculate mol drug chemistry. Combines 5 tools from 3 SCP server(s).

Optical System Analysis - Analyze optical system: calculate photon rate, frequency range, radiation pressure, and electron wavelength. Use this skill for optics tasks involving calculate incident photon rate calculate frequency range calculate radiation pressure electron wavelength. Combines 4 tools from 1 SCP server(s).

Biomarker Discovery Pipeline - Discover biomarkers: TCGA differential expression, NCBI gene data, OpenTargets associations, and clinical relevance. Use this skill for precision medicine tasks involving tcga differential expression analysis get gene metadata by gene name get associated targets by disease efoId clinvar search. Combines 4 tools from 4 SCP server(s).

Virus Genomics Analysis - Analyze virus genomics: NCBI virus dataset, annotation, taxonomy, and literature search. Use this skill for virology tasks involving get virus dataset report get virus annotation report get taxonomy search literature. Combines 4 tools from 2 SCP server(s).

Lead Compound Optimization - Optimize a lead compound: validate SMILES, compute drug-likeness, predict ADMET properties, and check ChEMBL bioactivity. Use this skill for medicinal chemistry tasks involving is valid smiles calculate mol drug chemistry pred molecule admet search activity. Combines 4 tools from 3 SCP server(s).

Generate new molecules sampling from the input molecule.

Calculate material density and volume from mass and geometric dimensions for materials mechanics analysis.

Analyze measurement errors, uncertainties, and statistical variations in experimental data for quality control.

Computational Analysis via Code Execution - Execute custom computational analysis code, analyze software, and search for reference implementations. Use this skill for computational science tasks involving exec code software analysis search dataset search literature. Combines 4 tools from 2 SCP server(s).

Calculate optical frequency and wavelength relationships for photonics and electromagnetic analysis.

Analyze protein-protein interaction enrichment using STRING database to identify functional networks and pathway associations.

Population Genetics Analysis - Analyze population genetics: Ensembl variation populations, linkage disequilibrium, and variant frequency data. Use this skill for population genetics tasks involving get info variation populations get ld get variation get variant recoder. Combines 4 tools from 1 SCP server(s).

Mutation Impact Analysis - Analyze mutation impact: predict structure, predict mutations from sequence and structure, and check variant effects with Ensembl VEP. Use this skill for molecular biology tasks involving pred protein structure esmfold zero shot sequence prediction predict zero shot structure get vep hgvs. Combines 4 tools from 3 SCP server(s).

Calculate seawater thermodynamic properties using TEOS-10 standard including density, salinity, sound speed, and freezing temperature for oceanography.

Chromosome Structure Analysis - Analyze chromosome: NCBI summary, UCSC cytoband, genome sequence, and Ensembl assembly info. Use this skill for cytogenetics tasks involving get chromosome summary get cytoband get chromosome sequence get info assembly. Combines 4 tools from 3 SCP server(s).

Signal Processing Analysis - Analyze signals: duty cycle, frequency range, electron wavelength, and measurement error analysis. Use this skill for signal processing tasks involving calculate duty cycle calculate frequency range electron wavelength calculate absolute error. Combines 4 tools from 3 SCP server(s).

Polypharmacology Analysis - Analyze a drug's multi-target pharmacology: get targets from ChEMBL, functional enrichment from STRING, and pathway links from KEGG. Use this skill for pharmacology tasks involving get target by name get functional enrichment kegg link get mechanism by id. Combines 4 tools from 3 SCP server(s).

Natural Product Analysis - Analyze natural products: name to SMILES, PubChem lookup, structural analysis, and KEGG natural product search. Use this skill for natural products chemistry tasks involving NameToSMILES search pubchem by name ChemicalStructureAnalyzer kegg find. Combines 4 tools from 4 SCP server(s).

Extract laboratory protocols from PDF documents using Thoth-Plan to convert experimental procedures into structured text.

Molecular Docking Pipeline - Complete docking workflow: retrieve protein structure, predict binding pockets, prepare receptor, and dock ligand. Use this skill for structural biology tasks involving retrieve protein data by pdbcode run fpocket convert pdb to pdbqt dock quick molecule docking. Combines 4 tools from 2 SCP server(s).

Calculate buoyancy forces and acceleration for fluid mechanics and hydrodynamics analysis.

Calculate different types of molecular properties based on SMILES strings, covering basic physicochemical properties, hydrophobicity, hydrogen bonding capability, molecular complexity, topological structures, charge distribution, and custom complexity metrics, respectively.

Binding Site Characterization - Characterize binding sites: predict pockets with fpocket and P2Rank, get binding site info from ChEMBL, and visualize. Use this skill for structural biology tasks involving run fpocket pred pocket prank get binding site by id visualize protein. Combines 4 tools from 3 SCP server(s).

Synthetic Biology Design - Design synthetic biology construct: gene lookup, codon optimization, protein property prediction, and structure prediction. Use this skill for synthetic biology tasks involving get sequence id DegenerateCodonCalculatorbyAminoAcid calculate protein sequence properties pred protein structure esmfold. Combines 4 tools from 4 SCP server(s).

Search KEGG database for gene information to retrieve pathway associations, functional annotations, and disease links.

Given a protein sequence and its structure, employ ProSST model to predict mutation effects and obtain the top-k mutated sequences.

Substructure-Activity Relationship - Analyze substructure-activity: ChEMBL substructure search, activity data, PubChem compounds, and similarity. Use this skill for medicinal chemistry tasks involving get substructure by smiles search activity search pubchem by smiles calculate smiles similarity. Combines 4 tools from 3 SCP server(s).

Protein Cross-Database Reference - Cross-reference protein: UniProt entry, NCBI gene, Ensembl xrefs, and PDB structure search. Use this skill for proteomics tasks involving get uniprotkb entry by accession get gene metadata by gene name get xrefs symbol retrieve protein data by pdbcode. Combines 4 tools from 4 SCP server(s).

Comprehensive Drug Safety Profile - Build a complete drug safety profile by combining FDA adverse reactions, boxed warnings, drug interactions, and contraindications. Use this skill for pharmacology tasks involving get adverse reactions by drug name get boxed warning info by drug name get drug interactions by drug name get contraindications by drug name. Combines 4 tools from 1 SCP server(s).

Use the local InnoClaw CLI to run app workflows and Deep Research sessions from the terminal. Trigger when the user wants command-line control over this repository instead of only using the web UI.

Set up and iterate on the minds app stack (desktop client, workspace server, mngr, forever-claude-template) with a running Docker agent

Create FIXME's in the codebase for each of the issues in the given input file.

Create 1-3 short asciinema demo recordings (5-20 seconds each) that demonstrate completed work. Use only when explicitly instructed to create demos.

Comprehensive code review with security, performance, and best practices focus

Scaffold a new microservice that follows project architecture patterns

SpringBlade 通用 Git 提交工具。基于 Gitmoji 规范生成提交信息。当用户要求提交代码、commit 变更、生成 commit message、或使用 /blade-commit 时触发。默认强制简单模式（gitmoji + 一句话描述），仅当显式传入 --d 或 --detail 参数时才启用详细模式（gitmoji + conventional commit + 变更列表）。只执行 commit，绝不 push 或执行其他远程操作。确保每次提交都带有 gitmoji 图标。

SpringBlade 全栈代码生成器。根据用户提供的模块名、实体名和字段列表，自动生成符合 SpringBlade 开源版框架规范的后端代码（Boot 单体/Cloud 微服务）、前端页面（Saber Options API/Composition API）和 MySQL 建表语句。当用户说"帮我生成代码"、"创建一个新模块"、"生成 CRUD"、"新建实体"、"建表语句"、"生成前端页面"、"生成后端接口"、"生成 SpringBlade 代码"、"写一个 xxx 管理功能"、"帮我设计 xxx 表"、"blade-design"等时触发。即使用户只是描述了业务字段或给出了表结构，也应触发此技能来生成对应的 SpringBlade 规范代码。

全面的 PDF 操作工具包，用于提取文本和表格、创建新 PDF、合并/拆分文档和处理表单。当 Claude 需要填写 PDF 表单或以编程方式大规模处理、生成或分析 PDF 文档时使用。

必须用于在每次功能、错误修复或拉取请求后进行严格的、具有安全意识的审查。在合并到主分支前应主动使用。它会交付一份完整的、带有严重性标签的报告，并将安全、性能或重度重构问题分派给专业子代理。

提供特定编程语言和框架的深度专业知识。当需要处理特定技术栈的复杂问题时使用

Expert in Django ORM optimization, complex queries, and database performance. Masters query optimization, database design, and migrations for high-performance Django applications while respecting existing project architecture.

Laravel backend specialist for any Laravel architecture. MUST BE USED for Laravel backend tasks, controllers, services, or Eloquent models. Handles traditional MVC, Inertia.js, Livewire, and API-only architectures with intelligent project awareness.

编写使用goroutine、channel和接口的惯用Go代码。优化并发，实现Go模式，并确保适当的错误处理。主动用于Go重构、并发问题或性能优化。

Expert Rails API developer specializing in RESTful APIs and GraphQL. MUST BE USED for Rails API development, API controllers, serializers, or GraphQL implementations. Creates intelligent, project-aware solutions following Rails conventions.

精通ES6+、异步模式和Node.js API的现代JavaScript。处理Promise、事件循环和浏览器/Node兼容性。主动用于JavaScript优化、异步调试或复杂的JS模式。

Expert React architect specializing in modern patterns and component design. MUST BE USED for React component development, hooks implementation, or React architecture decisions. Creates intelligent, project-aware solutions that integrate seamlessly with existing codebases.

Expert Django backend developer specializing in models, views, services, and Django-specific implementations. MUST BE USED for Django backend development tasks. Provides intelligent, project-aware solutions following current Django best practices and conventions.

Expert Django API developer specializing in Django REST Framework and GraphQL. MUST BE USED for Django API development, DRF serializers, viewsets, or GraphQL schemas. Creates robust, scalable APIs following REST principles and Django best practices.

Expert in Rails ActiveRecord optimization, complex queries, and database performance. Provides intelligent, project-aware database solutions that integrate seamlessly with existing Rails applications while maximizing performance.

提供安全审计、风险评估和合规检查能力。当需要进行安全审查、风险评估或合规验证时使用。

审查代码漏洞，实施安全认证，并确保符合OWASP标准。处理JWT、OAuth2、CORS、CSP和加密。主动用于安全审查、认证流程或漏洞修复。

Strategic environmental analysis using SWOT, PESTLE, and Porter's Five Forces. Creates structured assessments with Mermaid visualizations for competitive positioning and strategic planning.

优化SQL查询，设计高效索引，并处理数据库迁移。解决N+1问题、慢查询并实现缓存。主动用于数据库性能问题或Schema优化。