For data analysts

Use this skill any time a spreadsheet file is the primary input or output. This means any task where the user wants to: open, read, edit, or fix an existing .xlsx, .xlsm, .csv, or .tsv file (e.g., adding columns, computing formulas, formatting, charting, cleaning messy data); create a new spreadsheet from scratch or from other data sources; or convert between tabular file formats. Trigger especially when the user references a spreadsheet file by name or path — even casually (like "the xlsx in my downloads") — and wants something done to it or produced from it. Also trigger for cleaning or restructuring messy tabular data files (malformed rows, misplaced headers, junk data) into proper spreadsheets. The deliverable must be a spreadsheet file. Do NOT trigger when the primary deliverable is a Word document, HTML report, standalone Python script, database pipeline, or Google Sheets API integration, even if tabular data is involved.

Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating new PDFs, filling PDF forms, encrypting/decrypting PDFs, extracting images, and OCR on scanned PDFs to make them searchable. If the user mentions a .pdf file or asks to produce one, use this skill.

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

Use this skill any time a .pptx file is involved in any way — as input, output, or both. This includes: creating slide decks, pitch decks, or presentations; reading, parsing, or extracting text from any .pptx file (even if the extracted content will be used elsewhere, like in an email or summary); editing, modifying, or updating existing presentations; combining or splitting slide files; working with templates, layouts, speaker notes, or comments. Trigger whenever the user mentions "deck," "slides," "presentation," or references a .pptx filename, regardless of what they plan to do with the content afterward. If a .pptx file needs to be opened, created, or touched, use this skill.

Use this skill whenever the user wants to create, read, edit, or manipulate Word documents (.docx files). Triggers include: any mention of 'Word doc', 'word document', '.docx', or requests to produce professional documents with formatting like tables of contents, headings, page numbers, or letterheads. Also use when extracting or reorganizing content from .docx files, inserting or replacing images in documents, performing find-and-replace in Word files, working with tracked changes or comments, or converting content into a polished Word document. If the user asks for a 'report', 'memo', 'letter', 'template', or similar deliverable as a Word or .docx file, use this skill. Do NOT use for PDFs, spreadsheets, Google Docs, or general coding tasks unrelated to document generation.

This skill should be used when the user asks about "plugin settings", "store plugin configuration", "user-configurable plugin", ".local.md files", "plugin state files", "read YAML frontmatter", "per-project plugin settings", or wants to make plugin behavior configurable. Documents the .claude/plugin-name.local.md pattern for storing plugin-specific configuration with YAML frontmatter and markdown content.

This skill should be used when the user asks to "add MCP server", "integrate MCP", "configure MCP in plugin", "use .mcp.json", "set up Model Context Protocol", "connect external service", mentions "${CLAUDE_PLUGIN_ROOT} with MCP", or discusses MCP server types (SSE, stdio, HTTP, WebSocket). Provides comprehensive guidance for integrating Model Context Protocol servers into Claude Code plugins for external tool and service integration.

Use this skill when you see `/omo`. Multi-agent orchestration for "code analysis / bug investigation / fix planning / implementation". Choose the minimal agent set and order based on task type + risk; recipes below show common patterns.

Deeply analyzes existing codebase features by tracing execution paths, mapping architecture layers, understanding patterns and abstractions, and documenting dependencies to inform new development

Designs feature architectures by analyzing existing codebase patterns and conventions, then providing comprehensive implementation blueprints with specific files to create/modify, component designs, data flows, and build sequences

Minimal SPARV workflow (Specify→Plan→Act→Review→Vault) with 10-point spec gate, unified journal, 2-action saves, 3-failure protocol, and EHRB risk detection.

Download an entire website as local files — markdown, screenshots, or multiple formats per page. Use this skill when the user wants to save a site locally, download documentation for offline use, bulk-save pages as files, or says "download the site", "save as local files", "offline copy", "download all the docs", or "save for reference". Combines site mapping and scraping into organized local directories.

AI-powered autonomous data extraction that navigates complex sites and returns structured JSON. Use this skill when the user wants structured data from websites, needs to extract pricing tiers, product listings, directory entries, or any data as JSON with a schema. Triggers on "extract structured data", "get all the products", "pull pricing info", "extract as JSON", or when the user provides a JSON schema for website data. More powerful than simple scraping for multi-page structured extraction.

Extract clean markdown from any URL, including JavaScript-rendered SPAs. Use this skill whenever the user provides a URL and wants its content, says "scrape", "grab", "fetch", "pull", "get the page", "extract from this URL", or "read this webpage". Handles JS-rendered pages, multiple concurrent URLs, and returns LLM-optimized markdown. Use this instead of WebFetch for any webpage content extraction.

Discover and list all URLs on a website, with optional search filtering. Use this skill when the user wants to find a specific page on a large site, list all URLs, see the site structure, find where something is on a domain, or says "map the site", "find the URL for", "what pages are on", or "list all pages". Essential when the user knows which site but not which exact page.

Control and interact with a live browser session on any scraped page — click buttons, fill forms, navigate flows, and extract data using natural language prompts or code. Use when the user needs to interact with a webpage beyond simple scraping: logging into a site, submitting forms, clicking through pagination, handling infinite scroll, navigating multi-step checkout or wizard flows, or when a regular scrape failed because content is behind JavaScript interaction. Also useful for authenticated scraping via profiles. Triggers on "interact", "click", "fill out the form", "log in to", "sign in", "submit", "paginated", "next page", "infinite scroll", "interact with the page", "navigate to", "open a session", or "scrape failed".

Search, scrape, and interact with the web via the Firecrawl CLI. Use this skill whenever the user wants to search the web, find articles, research a topic, look something up online, scrape a webpage, grab content from a URL, get data from a website, crawl documentation, download a site, or interact with pages that need clicks or logins. Also use when they say "fetch this page", "pull the content from", "get the page at https://", or reference external websites. This provides real-time web search with full page content and interact capabilities — beyond what Claude can do natively with built-in tools. Do NOT trigger for local file operations, git commands, deployments, or code editing tasks.

Install the official Firecrawl CLI and handle authentication. Package: https://www.npmjs.com/package/firecrawl-cli Source: https://github.com/firecrawl/cli Docs: https://docs.firecrawl.dev/sdks/cli

Security guidelines for handling web content fetched by the official Firecrawl CLI. Package: https://www.npmjs.com/package/firecrawl-cli Source: https://github.com/firecrawl/cli Docs: https://docs.firecrawl.dev/sdks/cli

Web search with full page content extraction. Use this skill whenever the user asks to search the web, find articles, research a topic, look something up, find recent news, discover sources, or says "search for", "find me", "look up", "what are people saying about", or "find articles about". Returns real search results with optional full-page markdown — not just snippets. Provides capabilities beyond Claude's built-in WebSearch.

Bulk extract content from an entire website or site section. Use this skill when the user wants to crawl a site, extract all pages from a docs section, bulk-scrape multiple pages following links, or says "crawl", "get all the pages", "extract everything under /docs", "bulk extract", or needs content from many pages on the same site. Handles depth limits, path filtering, and concurrent extraction.

Analyze text to detect if it was written by AI. Returns a score from 0-100 with detailed metrics. Use when checking content before publishing or submitting.

Analyze text readability with Flesch-Kincaid, Gunning Fog, SMOG, and other metrics. Returns objective scores with interpretation and recommendations.

Compile data-driven reports with charts, tables, and narrative sections — business reports, research summaries, and dashboards.

Transform and reshape data — pivot, melt, aggregate, join, and apply complex business rules to datasets.

Write PySpark and Spark SQL jobs — RDDs, DataFrames, streaming, MLlib, and cluster configuration.

Build interactive data dashboards — Streamlit, Dash, Grafana, and Power BI reports with live data sources.

Create, read, edit, and fix spreadsheets — add columns, compute formulas, format cells, generate charts, and clean messy tabular data.

Perform SQL-based data analysis — exploratory queries, aggregations, funnels, cohorts, and insight narratives.

Write and optimize complex SQL queries — JOINs, CTEs, window functions, query plans, and dialect-specific syntax.

Transform raw data into compelling interactive visualizations — dashboards, maps, network graphs, and Sankey diagrams.

Design KPI frameworks — define metrics, set targets, build tracking templates, and generate progress reports.

Create high-fidelity UI mockups in HTML/CSS — dashboards, mobile screens, landing pages, and component previews.

Automate Jira — issue creation, sprint management, JQL queries, and project reporting via REST API.

Write and update release notes in whatsNew.ts with context-aware content generation

Review UI code for Web Interface Guidelines compliance. Use when asked to "review my UI", "check accessibility", "audit design", "review UX", or "check my site against best practices".

Manages shadcn components and projects — adding, searching, fixing, debugging, styling, and composing UI. Provides project context, component docs, and usage examples. Applies when working with shadcn/ui, component registries, presets, --preset codes, or any project with a components.json file. Also triggers for "shadcn init", "create an app with --preset", or "switch to --preset".

Create new skills, modify and improve existing skills, and measure skill performance. Use when users want to create a skill from scratch, edit, or optimize an existing skill, run evals to test a skill, benchmark skill performance with variance analysis, or optimize a skill's description for better triggering accuracy.

Next.js best practices - file conventions, RSC boundaries, data patterns, async APIs, metadata, error handling, route handlers, image/font optimization, bundling

React and Next.js performance optimization guidelines from Vercel Engineering. This skill should be used when writing, reviewing, or refactoring React/Next.js code to ensure optimal performance patterns. Triggers on tasks involving React components, Next.js pages, data fetching, bundle optimization, or performance improvements.

Guide for building features, pages, tables, forms, themes, and navigation in this Next.js 16 shadcn dashboard template. Use this skill whenever the user wants to add a new page, create a feature module, build a data table, add a form, configure navigation items, add a theme, set up RBAC access control, or work with the dashboard's patterns and conventions. Also triggers when adding routes under /dashboard, working with Clerk auth/orgs/billing, creating mock APIs, or modifying the sidebar. Even if the user doesn't mention "dashboard" explicitly — if they're adding UI, pages, or features to this project, use this skill.

Analyze and optimize Python code performance in critical paths

Set up a dev environment in an existing worktree (make dev + copy secrets)

Generate release notes between two git tags with categorized PR summaries and author attribution

Use when reading, editing, or creating files in dlt/_workspace/helpers/dashboard/ or tests/workspace/helpers/dashboard/ or tests/e2e/

Create a git worktree with a new branch for implementing a fix or feature for a GitHub issue

Reference for the `.ato` declarative DSL: type system, connection semantics, constraint model, and standard library. Use when authoring or reviewing `.ato` code.

How the Zig-backed instance graph works (GraphView/NodeReference/EdgeReference), the real Python API surface, and the invariants around allocation, attributes, and cleanup. Use when working with low-level graph APIs, memory management, or building systems that traverse the instance graph.

Instructions for electronics-specific logic and build processes: netlists, PCBs, build steps, and exporters. Use when implementing or modifying build steps, exporters, PCB generation, or BOM/netlist output.

Show specification status and progress

Analyze implementation gap between requirements and existing codebase. Use when planning integration with existing systems.

Generate comprehensive technical design translating requirements (WHAT) into architecture (HOW) with discovery process. Use when creating architecture from requirements.

Generate EARS-format requirements based on project description and steering context. Use when generating requirements from project description.

Validate feature-level integration after all tasks are implemented. Checks cross-task consistency, full test suite, and overall spec coverage.

Chart and data visualization patterns for Remotion. Use when creating bar charts, pie charts, line charts, stock graphs, or any data-driven animations.

Systematically debug a problem using a four-phase workflow

Query openspec documents and answer questions based on spec content

分析心理健康数据、识别心理模式、评估心理健康状况、提供个性化心理健康建议。支持与睡眠、运动、营养等其他健康数据的关联分析。

分析一段时间内健康数据的趋势和模式。关联药物、症状、生命体征、化验结果和其他健康指标的变化。识别令人担忧的趋势、改善情况，并提供数据驱动的洞察。当用户询问健康趋势、模式、随时间的变化或"我的健康状况有什么变化？"时使用。支持多维度分析（体重/BMI、症状、药物依从性、化验结果、情绪睡眠），相关性分析，变化检测，以及交互式HTML可视化报告（ECharts图表）。

分析减肥数据、计算代谢率、追踪能量缺口、管理减肥阶段

分析健康目标数据、识别目标模式、评估目标进度,并提供个性化目标管理建议。支持与营养、运动、睡眠等健康数据的关联分析。

分析康复训练数据、识别康复模式、评估康复进展，并提供个性化康复建议

分析运动数据、识别运动模式、评估健身进展，并提供个性化训练建议。支持与慢性病数据的关联分析。

分析睡眠数据、识别睡眠模式、评估睡眠质量，并提供个性化睡眠改善建议。支持与其他健康数据的关联分析。

分析营养数据、识别营养模式、评估营养状况，并提供个性化营养建议。支持与运动、睡眠、慢性病数据的关联分析。

分析中医体质数据、识别体质类型、评估体质特征,并提供个性化养生建议。支持与营养、运动、睡眠等健康数据的关联分析。

分析家族病史、评估遗传风险、识别家庭健康模式、提供个性化预防建议

Integrate digital health data sources (Apple Health, Fitbit, Oura Ring) and connect to WellAlly.tech knowledge base. Import external health device data, standardize to local format, and recommend relevant WellAlly.tech knowledge base articles based on health data. Support generic CSV/JSON import, provide intelligent article recommendations, and help users better manage personal health data.

Use when implementing GitHub OAuth + GitHub App authentication with Nango - provides two-connection pattern for user login and repo access with webhook handling

Best practices for structuring prpm.json package manifests with required fields, tags, organization, multi-package management, enhanced file format, eager/lazy activation, and conversion hints

Use when an agent needs to self-bootstrap agent-relay and autonomously manage a team of workers - covers infrastructure startup, agent spawning, lifecycle monitoring, and team coordination without human intervention

Use when testing web applications with visual verification - automates Chrome browser interactions, element selection, and screenshot capture for confirming UI functionality

Use when seeing WebSocket errors like "Invalid frame header", "RSV1 must be clear", or "WS_ERR_UNEXPECTED_RSV_1" - covers multiple WebSocketServer conflicts, compression issues, and raw frame debugging techniques

Use when creating or publishing Claude Code hooks - covers executable format, event types, JSON I/O, exit codes, security requirements, and PRPM package structure

Use this agent when working with prompt injection detection integration tests, including running tests, debugging failures, or adding new test samples.

Use when asked to review a PR, or when /review is invoked with a PR number or URL. Performs a focused code review checking for bugs, security, performance, and test gaps, then posts findings as a PR comment and formal GitHub review.

Calculate volumes of geometric shapes for engineering design and mathematical analysis.

Query EBI GWAS Catalog for GWAS statistical associations (p-value, effect size, risk allele) between a variant and traits/diseases.

Orphan Drug & Rare Disease Analysis - Analyze orphan drugs: Monarch disease phenotypes, OpenTargets targets, FDA drug data, and clinical studies. Use this skill for orphan drug development tasks involving get joint associated diseases by HPO ID list get associated targets by disease efoId get clinical studies info by drug name pubmed search. Combines 4 tools from 4 SCP server(s).

BioSample & Genome Cross-Reference - Cross-reference biosample and genome data: NCBI biosample, genome report, sequence reports, and taxonomy. Use this skill for genomics tasks involving get biosample report get genome dataset report by accession get genome sequence reports get taxonomy. Combines 4 tools from 1 SCP server(s).

Use when the user provides a natural language description of a 3D object or mechanical part and wants to generate a CAD model. Converts the description into CadQuery Python code, automatically detects or sets up the CadQuery environment, executes the script, and produces STL and STEP output files.

Systems Pharmacology Analysis - Systems pharmacology: drug targets, protein interactions, pathway enrichment, and gene expression. Use this skill for systems pharmacology tasks involving get target by name get string network interaction get functional enrichment get gene expression across cancers. Combines 4 tools from 3 SCP server(s).

Geometry & Trigonometry Suite - Solve geometry problems: calculate area, height from sine, angle in degrees, and increase factor. Use this skill for mathematics tasks involving calculate area calculate height from length and sine calculate phi deg calculate increase factor. Combines 4 tools from 1 SCP server(s).

Protein Interaction Network Analysis - Build protein interaction network: map identifiers with STRING, get PPI network, compute enrichment, and link to KEGG pathways. Use this skill for systems biology tasks involving mapping identifiers get string network interaction get ppi enrichment kegg link. Combines 4 tools from 2 SCP server(s).

Compute the Tanimoto similarities between a target molecule and a list of candidate molecules using Morgan fingerprints.

Nuclear Physics Calculations - Nuclear physics: energy conversion MeV to J, calculate total power, photon rate, and error analysis. Use this skill for nuclear physics tasks involving convert energy MeV to J calculate total power calculate incident photon rate calculate absolute error. Combines 4 tools from 3 SCP server(s).

Given an rsID, query multiple databases (dbSNP, FAVOR, GWAS Catalog, ClinVar, gnomAD, PharmGKB, ClinGen) for comprehensive annotation. Use when user asks a general question about a variant without specifying which aspect.

Statistical Error Analysis - Analyze measurement errors: absolute error, scientific notation, max value, mean square, and formatting. Use this skill for statistics tasks involving calculate absolute error convert to scientific notation calculate max value calculate mean square format scientific notation. Combines 5 tools from 1 SCP server(s).

Compute the drug-likeness metrics (QED score and Number of violations of Lipinski's Rule of Five) of the input candidate molecules (SMILES format).

Calculate disease reversal scores for the provided molecules relative to a specific disease.

Cross-Species Comparative Genomics - Compare genomes across species: Ensembl compara, alignment, gene trees, and NCBI taxonomy. Use this skill for comparative genomics tasks involving get info compara species sets get alignment region get genetree member symbol get taxonomy. Combines 4 tools from 2 SCP server(s).

Pandemic Preparedness Analysis - Pandemic analysis: virus genome, taxonomy, drug candidates, and literature intelligence. Use this skill for public health tasks involving get virus dataset report get virus by taxon genome get mechanism of action by drug name tavily search search literature. Combines 5 tools from 4 SCP server(s).

Calculate peptide sequence properties including molecular weight, isoelectric point, extinction coefficient, and chemical formula.

Use when the user wants the full research ideation workflow grounded in one seed paper, including complete ideation, feasibility review, experiment planning, and final synthesis, or makes an equivalent ideation request in another language.

Ring System Analysis - Analyze ring systems: count aliphatic carbocycles, analyze aromaticity, compute topology, and structure complexity. Use this skill for organic chemistry tasks involving GetAliphaticCarbocyclesNum AromaticityAnalyzer calculate mol topology calculate mol structure complexity. Combines 4 tools from 3 SCP server(s).

Structural Homology & Evolution Analysis - Analyze protein evolution: get gene tree from Ensembl, find homologs, compare sequences, and predict structure. Use this skill for evolutionary biology tasks involving get homology symbol get genetree member symbol calculate protein sequence properties pred protein structure esmfold. Combines 4 tools from 3 SCP server(s).

Predict protein-ligand binding affinity using Boltz-2 model to assess molecular interactions and binding probability for drug discovery.

Electromagnetic Field Analysis - Analyze EM fields: vacuum permittivity, total charge, radiation pressure, and photon calculations. Use this skill for electromagnetics tasks involving calculate vacuum permittivity calculate total charge calculate radiation pressure calculate total power. Combines 4 tools from 2 SCP server(s).

Alanine Scanning Mutagenesis Pipeline - Alanine scanning: design scan, compute properties for each mutant, predict interactions, and compare. Use this skill for protein biochemistry tasks involving AlanineScanningDesigner ComputeProtPara PredictDrugTargetInteraction calculate protein sequence properties. Combines 4 tools from 3 SCP server(s).

Calculate comprehensive protein sequence properties including isoelectric point, molecular weight, hydrophobicity, and physicochemical parameters.

Multi-Species Gene Analysis - Analyze gene across species: Ensembl homologs, NCBI orthologs, cross-species STRING similarity, and taxonomy. Use this skill for comparative genomics tasks involving get homology symbol get gene orthologs get best similarity hits between species get taxonomy. Combines 4 tools from 3 SCP server(s).

Combinatorial Chemistry Library Design - Design combinatorial library: validate core SMILES, generate variants, compute properties, and predict ADMET for library. Use this skill for combinatorial chemistry tasks involving is valid smiles calculate mol basic info calculate mol drug chemistry pred molecule admet. Combines 4 tools from 2 SCP server(s).

Comprehensive protein analysis combining InterProScan domain identification with BLAST similarity search to provide complete functional and evolutionary annotation.

Gene-Disease Association Analysis - Analyze gene-disease associations: NCBI gene metadata, OpenTargets disease associations, TCGA expression, and Monarch phenotypes. Use this skill for medical genetics tasks involving get gene metadata by gene name get associated targets by disease efoId get gene expression across cancers get joint associated diseases by HPO ID list. Combines 4 tools from 4 SCP server(s).

Protein Classification Analysis - Classify protein: ChEMBL protein classification, UniProt entry, InterPro domains, and Ensembl biotypes. Use this skill for protein science tasks involving search protein classification get uniprotkb entry by accession query interpro get info biotypes. Combines 4 tools from 4 SCP server(s).

Functional Group Profiling - Profile functional groups: radical assignment, H-bond analysis, aromaticity, and abbreviation condensation. Use this skill for organic chemistry tasks involving AssignRadicals GetHBANum AromaticityAnalyzer CondenseAbbreviationSubstanceGroups. Combines 4 tools from 2 SCP server(s).

Drug Target Identification Pipeline - Identify drug targets for a disease by querying OpenTargets for associated targets, then retrieve detailed target info from ChEMBL and protein data from UniProt. Use this skill for drug discovery tasks involving get associated targets by disease efoId get target by name get general info by protein or gene name. Combines 3 tools from 3 SCP server(s).

Comparative Drug Analysis - Compare drugs: structure analysis, PubChem data, FDA safety, and ChEMBL bioactivity. Use this skill for comparative pharmacology tasks involving ChemicalStructureAnalyzer get compound by name get adverse reactions by drug name search activity. Combines 4 tools from 4 SCP server(s).

Experimental Data Processing - Process experimental data: absolute error, mean square, max value, scientific notation formatting. Use this skill for experimental physics tasks involving calculate absolute error calculate mean square calculate max value format scientific notation convert to scientific notation. Combines 5 tools from 1 SCP server(s).

Retrieve gene information from NCBI Gene database by gene IDs to obtain genomic details, function, and expression data.

Chemical Structure Comparison - Compare chemical structures: get SMILES, analyze structures, compute similarity, and check PubChem records. Use this skill for cheminformatics tasks involving NameToSMILES ChemicalStructureAnalyzer calculate smiles similarity get compound by name. Combines 4 tools from 4 SCP server(s).

Gene Therapy Target Analysis - Analyze gene therapy target: gene info, variant pathogenicity, protein structure, and clinical evidence. Use this skill for gene therapy tasks involving get gene metadata by gene name get vep hgvs Protein structure prediction ESMFold clinvar search. Combines 4 tools from 4 SCP server(s).

Genome Annotation Pipeline - Annotate a genome: NCBI annotation report, Ensembl gene lookup, UCSC tracks, and KEGG pathway links. Use this skill for genomics tasks involving get genome annotation report get lookup symbol list tracks kegg link. Combines 4 tools from 4 SCP server(s).

Charge Carrier Mobility Analysis - Analyze carrier mobility: calculate new mobility, compute vacuum permittivity, and error analysis. Use this skill for semiconductor physics tasks involving calculate new mobility calculate vacuum permittivity calculate absolute error calculate mean square. Combines 4 tools from 2 SCP server(s).

Energy Unit Conversion Pipeline - Convert between energy units and analyze: MeV to Joules, scientific notation, and error calculation. Use this skill for physics tasks involving convert energy MeV to J convert to scientific notation format scientific notation calculate absolute error. Combines 4 tools from 2 SCP server(s).

Calculate sound speed in seawater from practical salinity, temperature, and pressure using the Gibbs Seawater Oceanographic Toolbox.

SNP Functional Impact Analysis - Analyze SNP function: VEP prediction, variation details, phenotype association, and literature evidence. Use this skill for functional genomics tasks involving get vep id get variation get phenotype accession pubmed search. Combines 4 tools from 2 SCP server(s).

Perform meta-analysis on scientific studies to synthesize research findings and generate comprehensive reports with statistical summaries.

Thermal & Heat Transfer Analysis - Analyze thermal system: calculate heat released, convert energy units, compute potential energy, and dynamic viscosity. Use this skill for thermal engineering tasks involving calculate heat released convert energy MeV to J calculate potential energy calculate dynamic viscosity. Combines 4 tools from 1 SCP server(s).

Bioassay Data Analysis - Analyze bioassay data: PubChem assay summary, ChEMBL activity search, compound properties, and target info. Use this skill for bioassay science tasks involving get assay summary by cid search activity calculate mol basic info get target by name. Combines 4 tools from 3 SCP server(s).

Precision Oncology Workflow - Precision oncology: tumor expression profiling, variant analysis, targeted therapy lookup, and clinical trials. Use this skill for precision oncology tasks involving get gene expression across cancers get vep hgvs get associated drugs by target name get clinical studies info by drug name pubmed search. Combines 5 tools from 5 SCP server(s).

Protein Complex Visualization & Analysis - Analyze protein complex: download structure, visualize complex, extract chains, and calculate quality metrics. Use this skill for structural biology tasks involving retrieve protein data by pdbcode visualize complex extract pdb chains calculate pdb basic info. Combines 4 tools from 1 SCP server(s).

Disease-Drug Landscape Analysis - Map the drug landscape for a disease: OpenTargets disease drugs, FDA indications, and clinical studies. Use this skill for drug discovery tasks involving get associated drugs by target name get drug names by indication get clinical studies info by drug name. Combines 3 tools from 2 SCP server(s).

AlphaFold Structure Analysis Pipeline - AlphaFold pipeline: download predicted structure, predict pockets, extract sequence, and compute properties. Use this skill for computational biology tasks involving download alphafold structure run fpocket extract pdb sequence calculate pdb basic info. Combines 4 tools from 3 SCP server(s).

Pharmacogenomics Analysis - Pharmacogenomics analysis: FDA pharmacogenomics info, variant effects, ClinVar pathogenicity, and gene expression. Use this skill for pharmacogenomics tasks involving get pharmacogenomics info by drug name get vep hgvs clinvar search get gene expression across cancers. Combines 4 tools from 4 SCP server(s).

Calculate basic molecular properties from SMILES including molecular weight, formula, atom counts, and exact mass.

Molecular Fingerprint Analysis - Fingerprint analysis: topology descriptors, structure complexity, similarity calculation, and AromaticityAnalysis. Use this skill for cheminformatics tasks involving calculate mol topology calculate mol structure complexity calculate smiles similarity AromaticityAnalyzer. Combines 4 tools from 2 SCP server(s).

SMILES Comprehensive Analysis - Comprehensive SMILES analysis: validate, convert name, compute all molecular descriptors, and predict ADMET. Use this skill for cheminformatics tasks involving is valid smiles ChemicalStructureAnalyzer calculate mol basic info pred molecule admet. Combines 4 tools from 3 SCP server(s).

One Health Pathogen Analysis - One Health analysis: pathogen genome, cross-species gene comparison, antimicrobial drugs, and environmental context. Use this skill for one health tasks involving get genome dataset report by taxon get homology symbol get mechanism of action by drug name tavily search get taxonomy. Combines 5 tools from 4 SCP server(s).

Enzyme Inhibitor Design - Design enzyme inhibitor: target structure, pocket prediction, compound screening, and ADMET assessment. Use this skill for enzyme pharmacology tasks involving retrieve protein data by pdbcode pred pocket prank quick molecule docking pred molecule admet calculate mol drug chemistry. Combines 5 tools from 2 SCP server(s).

Convert between molecular formats including SMILES, InChI, InChIKey, and SELFIES for cheminformatics applications.

Rare Disease Genetic Analysis - Analyze rare disease genetics: Monarch phenotype-disease mapping, ClinVar variants, NCBI gene data, and OpenTargets. Use this skill for rare disease genetics tasks involving get HPO ID by phenotype get joint associated diseases by HPO ID list clinvar search get associated targets by disease efoId. Combines 4 tools from 3 SCP server(s).

Infectious Disease Analysis - Analyze infectious disease: virus data, taxonomy, antimicrobial drugs, and resistance literature. Use this skill for infectious disease tasks involving get virus dataset report get taxonomy get mechanism of action by drug name pubmed search. Combines 4 tools from 3 SCP server(s).

Metabolomics Pathway Analysis - Analyze metabolomics: compound identification, KEGG pathway mapping, enzyme links, and PubChem data. Use this skill for metabolomics tasks involving search pubchem by name kegg find kegg link kegg get. Combines 4 tools from 2 SCP server(s).

Gene Comprehensive Lookup - Comprehensive gene lookup: NCBI gene data, Ensembl gene info, UniProt protein data, and KEGG pathway links. Use this skill for bioinformatics tasks involving get gene metadata by gene name get lookup symbol get general info by protein or gene name kegg find. Combines 4 tools from 4 SCP server(s).

Calculate atmospheric parameters including Coriolis parameter, geostrophic wind, heat index, potential temperature, and dewpoint for meteorology and climate science.

CAS Number Compound Lookup - Look up compounds by CAS: convert CAS to price/availability, get PubChem data, get ChEMBL info, and structure analysis. Use this skill for chemical information tasks involving CASToPrice get compound by name get molecule by name ChemicalStructureAnalyzer. Combines 4 tools from 4 SCP server(s).

Query dbSNP + NCBI Gene to get variant genomic position (chromosome, coordinates, ref/alt alleles, mutation type) and associated gene coordinates.

UniProt Deep Protein Analysis - Deep UniProt analysis: entry data, UniRef clusters, UniParc cross-references, and gene-centric view. Use this skill for protein science tasks involving get uniprotkb entry by accession get uniref cluster by id get uniparc entry by upi get gene centric by accession. Combines 4 tools from 1 SCP server(s).

Assess wind energy potential and perform site analysis using atmospheric science calculations.

Protein Structure Quality Assessment - Assess structure quality: basic info, geometry analysis, quality metrics, composition, and visualization. Use this skill for structural biology tasks involving calculate pdb basic info calculate pdb structural geometry calculate pdb quality metrics calculate pdb composition info visualize protein. Combines 5 tools from 1 SCP server(s).

Cross-Species Protein Comparison - Compare proteins across species: get orthologs from NCBI, compute properties for each, and compare similarity. Use this skill for comparative biology tasks involving get gene orthologs calculate protein sequence properties calculate smiles similarity get homology id. Combines 4 tools from 3 SCP server(s).

Use ESMFold model to predict 3D structure of the input protein sequence.

Analyze protein sequences using InterProScan to identify functional domains, protein families, and Gene Ontology (GO) annotations.

Antibody Drug Development - Develop antibody drug: target protein analysis, biotherapeutic lookup, protein properties, and interaction prediction. Use this skill for biologics tasks involving get uniprotkb entry by accession get biotherapeutic by name ComputeProtPara ComputeHydrophilicity. Combines 4 tools from 3 SCP server(s).

Calculate the freezing point temperature of seawater from absolute salinity and pressure using GSW thermodynamic equations.

Transcriptome Analysis Pipeline - Analyze transcriptome: Ensembl transcript lookup, sequence retrieval, haplotype analysis, and UCSC track data. Use this skill for transcriptomics tasks involving get lookup id get sequence id get transcript haplotypes get track data. Combines 4 tools from 2 SCP server(s).

Analyze DNA and RNA sequences including molecular weight calculation, reverse complement generation, and oligonucleotide properties.

NCBI Gene Deep Dive - Deep dive into NCBI gene: metadata, dataset report, product report, orthologs, and gene links. Use this skill for gene biology tasks involving get gene metadata by gene name get gene dataset report by id get gene product report by id get gene orthologs get gene links by id. Combines 5 tools from 1 SCP server(s).

Antibody-Target Analysis - Analyze an antibody target: UniProt protein info, InterPro domains, protein properties, and biotherapeutic data from ChEMBL. Use this skill for immunology tasks involving get uniprotkb entry by accession query interpro ComputeProtPara get biotherapeutic by name. Combines 4 tools from 4 SCP server(s).

Comprehensive molecular property analysis covering basic info, hydrophobicity, H-bonding, structural complexity, topology, drug-likeness, charge distribution, and complexity metrics.

Proteome-Level Analysis - Analyze at proteome level: get proteome from UniProt, gene-centric view, functional annotation from STRING. Use this skill for proteomics tasks involving get proteome by id get gene centric by proteome get functional annotation. Combines 3 tools from 2 SCP server(s).

Tissue-Specific Expression Analysis - Analyze tissue-specific expression: ChEMBL tissue data, TCGA cancer expression, Ensembl gene info, and NCBI gene data. Use this skill for tissue biology tasks involving get tissue by id get gene expression across cancers get lookup symbol get gene metadata by gene name. Combines 4 tools from 4 SCP server(s).

Structural Pharmacogenomics - Link structure to pharmacogenomics: variant effect, protein structure change, drug binding, and clinical data. Use this skill for pharmacogenomics tasks involving get vep hgvs pred protein structure esmfold boltz binding affinity get pharmacogenomics info by drug name. Combines 4 tools from 3 SCP server(s).

Affinity Maturation Pipeline - Affinity maturation: compute binding affinity, predict mutations, compute hydrophilicity, and predict drug-target interaction. Use this skill for antibody engineering tasks involving ComputeAffinityCalculator zero shot sequence prediction ComputeHydrophilicity PredictDrugTargetInteraction. Combines 4 tools from 3 SCP server(s).

ADMET & Drug-Likeness Report - Generate comprehensive ADMET and drug-likeness report: molecular properties, H-bond analysis, hydrophobicity, topology, and ADMET prediction. Use this skill for medicinal chemistry tasks involving calculate mol basic info calculate mol hbond calculate mol hydrophobicity calculate mol topology pred molecule admet. Combines 5 tools from 2 SCP server(s).

Comprehensive drug screening pipeline from molecular filtering through QED/ADMET criteria to protein-ligand docking, identifying promising drug candidates.

Enzyme Active Site Engineering - Engineer enzyme: identify active site residues, predict pocket, analyze binding site, and predict mutations. Use this skill for enzymology tasks involving predict functional residue run fpocket get binding site by id pred mutant sequence. Combines 4 tools from 3 SCP server(s).

Gene Ontology Analysis - Analyze GO terms: ChEMBL GO slim, STRING functional enrichment, STRING annotation, and Ensembl ontology. Use this skill for functional genomics tasks involving get go slim by id get functional enrichment get functional annotation get ontology name. Combines 4 tools from 3 SCP server(s).

Use when the user wants the full multi-stage paper discussion workflow, a comprehensive structured discussion of one paper, or an equivalent full-discussion request in another language.

Analyze chemical structures from compound names to retrieve SMILES, molecular formulas, molecular weight, and LogP values.

Drug-Drug Interaction Checker - Check interactions between multiple drugs using FDA interaction data, PubChem compound info, and ChEMBL target overlap analysis. Use this skill for clinical pharmacology tasks involving get drug interactions by drug name get compound by name get target by name. Combines 3 tools from 3 SCP server(s).

Polymer & Material Property Analysis - Analyze polymer properties: composition, symmetry, density, and lattice parameters for material design. Use this skill for polymer science tasks involving MaterialCompositionAnalyzer CalculateSymmetry CalculateDensity MofLattice. Combines 4 tools from 2 SCP server(s).

Virtual Screening Pipeline - Virtual screening: search PubChem by substructure, compute similarity, filter by drug-likeness, and predict binding affinity. Use this skill for drug discovery tasks involving search pubchem by smiles calculate smiles similarity calculate mol drug chemistry boltz binding affinity. Combines 4 tools from 3 SCP server(s).

Retrieve protein sequences and functional information from UniProt database by protein name, enabling protein analysis and bioinformatics workflows.

Use when the research goal, evaluation target, scope, resources, timeline, or decision criteria are ambiguous, conflicting, or not operationally testable.

Calculate electrical capacitance from geometric parameters and dielectric properties for circuit design.

Chemical Patent & Novelty Analysis - Analyze chemical novelty: PubChem substructure CAS search, ChEMBL similarity search, compound synonyms, and literature. Use this skill for patent chemistry tasks involving get substructure cas get similarity by smiles get compound synonyms by name search literature. Combines 4 tools from 3 SCP server(s).

Create new skills, improve existing skills, and measure skill performance. Use when users want to create a skill from scratch, update or optimize an existing skill, run evals to test a skill, or benchmark skill performance with variance analysis.

Disease-Specific Compound Screening - Screen compounds for disease: get DLEPS score for disease relevance, predict ADMET, and check drug-likeness. Use this skill for drug discovery tasks involving calculate dleps score pred molecule admet calculate mol drug chemistry get compound by name. Combines 4 tools from 3 SCP server(s).

Regulatory Region Analysis - Analyze regulatory regions: get overlapping features, binding matrix, sequence, and phenotype associations. Use this skill for epigenomics tasks involving get overlap region get species binding matrix get sequence get phenotype region. Combines 4 tools from 2 SCP server(s).

Retrieve gene expression data from TCGA (The Cancer Genome Atlas) to analyze cancer-specific expression patterns.

Cell Line Assay Analysis - Analyze cell line assays: ChEMBL cell line info, assay search, activity data, and target info. Use this skill for cell biology tasks involving get cell line by id search assay search activity get target by name. Combines 4 tools from 1 SCP server(s).

Cancer Therapy Design - Design cancer therapy: identify targets, find drugs, check safety, and analyze differential expression. Use this skill for oncology tasks involving get associated targets by disease efoId get associated drugs by target name get adverse reactions by drug name tcga differential expression analysis. Combines 4 tools from 3 SCP server(s).

Organism Classification & Database - Classify organism: NCBI taxonomy, Ensembl taxonomy, ChEMBL organisms, and genome info. Use this skill for taxonomy tasks involving get taxonomy get taxonomy id get organism by id get genome dataset report by taxon. Combines 4 tools from 3 SCP server(s).

Protein Solubility Optimization - Optimize protein solubility: calculate properties, predict solubility, predict hydrophilicity, and suggest mutations. Use this skill for protein engineering tasks involving calculate protein sequence properties predict protein function ComputeHydrophilicity zero shot sequence prediction. Combines 4 tools from 3 SCP server(s).

Full Protein Characterization - Complete protein characterization: validate sequence, compute all properties, predict structure, and analyze pockets. Use this skill for protein biochemistry tasks involving is valid protein sequence analyze protein ComputeProtPara pred protein structure esmfold run fpocket. Combines 5 tools from 4 SCP server(s).

Compound-to-Drug Analysis Pipeline - Full compound-to-drug pipeline: name-to-SMILES conversion, structure analysis, drug-likeness, and FDA drug lookup. Use this skill for drug development tasks involving NameToSMILES ChemicalStructureAnalyzer calculate mol drug chemistry get drug by name. Combines 4 tools from 4 SCP server(s).

Gene Family Evolution Analysis - Analyze gene family evolution: CAFE gene tree, homology, Ensembl gene tree, and taxonomy. Use this skill for molecular evolution tasks involving get cafe genetree member symbol get homology symbol get genetree member symbol get taxonomy classification. Combines 4 tools from 1 SCP server(s).

Protein Structure Comprehensive Analysis - Comprehensive structure analysis: download PDB, extract chains, calculate geometry, quality metrics, and composition. Use this skill for structural biology tasks involving retrieve protein data by pdbcode extract pdb chains calculate pdb structural geometry calculate pdb quality metrics calculate pdb composition info. Combines 5 tools from 1 SCP server(s).

Implement data transmission between the local computer and the MCP Server using Base64 encoding

Use when the Researcher must convert a confirmed scientific goal into a staged, executable research plan with role assignments, milestones, resources, checkpoints, and risk controls.

Calculate advanced molecular descriptors including shape indices, connectivity indices, and structural features for QSAR and drug discovery.

Electrical Circuit Analysis - Analyze electrical circuit: compute capacitance, convert resistance units, calculate total charge, and duty cycle. Use this skill for electrical engineering tasks involving convert resistance kOhm to Ohm calculate geometric term calculate absolute error. Combines 3 tools from 3 SCP server(s).

Protein Function Annotation Pipeline - Annotate protein function: UniProt metadata, InterPro domains, functional prediction, and GO enrichment. Use this skill for proteomics tasks involving query uniprot query interpro predict protein function get functional enrichment. Combines 4 tools from 2 SCP server(s).

Use when the user wants question-driven help on one paper, including paper understanding, follow-up questions, method or experiment clarification, limitation analysis, or comparison against related work in any language.

InterProScan Analysis Pipeline - Run InterProScan for domain analysis, then enrich with UniProt data and STRING interactions. Use this skill for functional proteomics tasks involving interproscan analyze get uniprotkb entry by accession get functional enrichment query interpro. Combines 4 tools from 4 SCP server(s).

Calculate mass percentages and stoichiometric ratios for chemical reactions and compound compositions.

Query NCBI ClinVar for variant clinical pathogenicity classification (Pathogenic/Benign/VUS), review status and associated diseases.

Use before plan submission, major plan revision, and major stage transitions. Verify alignment, feasibility, rigor, completeness, and prevent unjustified regressions to earlier workflow phases.

Mouse Model Disease Analysis - Analyze mouse disease models: MouseMine search, NCBI mouse gene data, Ensembl cross-species comparison, and orthologs. Use this skill for model organisms tasks involving mousemine search get gene metadata by gene name get homology symbol get gene orthologs. Combines 4 tools from 3 SCP server(s).

PubChem Deep Dive Analysis - Deep dive into PubChem: compound info, bioassay summary, 3D conformers, synonyms, and general description. Use this skill for chemical databases tasks involving get pubchem compound by cid get assay summary by cid get conformers by cid get compound synonyms by name get general info by compound name. Combines 5 tools from 1 SCP server(s).

Microbiome Genomics Analysis - Analyze microbial genome: NCBI genome data, taxonomy, KEGG metabolic pathways, and annotation. Use this skill for metagenomics tasks involving get genome dataset report by taxon get taxonomy kegg find get genome annotation report. Combines 4 tools from 2 SCP server(s).

BLAST & Protein Analysis Pipeline - BLAST search followed by comprehensive protein analysis: BLAST, then structure prediction, properties, and function. Use this skill for sequence bioinformatics tasks involving blast search pred protein structure esmfold calculate protein sequence properties predict protein function. Combines 4 tools from 4 SCP server(s).

Gene Expression Atlas - Build gene expression atlas: TCGA cancer expression, NCBI gene info, Ensembl gene details, and literature search. Use this skill for transcriptomics tasks involving get gene expression across cancers get gene metadata by gene name get lookup symbol search literature. Combines 4 tools from 4 SCP server(s).

Gene-to-Drug Discovery Pipeline - Full gene-to-drug pipeline: gene lookup, protein structure, binding pocket, virtual screening, and drug-likeness. Use this skill for translational medicine tasks involving get gene metadata by gene name pred protein structure esmfold run fpocket boltz binding affinity calculate mol drug chemistry. Combines 5 tools from 3 SCP server(s).

Optical System Analysis - Analyze optical system: calculate photon rate, frequency range, radiation pressure, and electron wavelength. Use this skill for optics tasks involving calculate incident photon rate calculate frequency range calculate radiation pressure electron wavelength. Combines 4 tools from 1 SCP server(s).

Biomarker Discovery Pipeline - Discover biomarkers: TCGA differential expression, NCBI gene data, OpenTargets associations, and clinical relevance. Use this skill for precision medicine tasks involving tcga differential expression analysis get gene metadata by gene name get associated targets by disease efoId clinvar search. Combines 4 tools from 4 SCP server(s).

Virus Genomics Analysis - Analyze virus genomics: NCBI virus dataset, annotation, taxonomy, and literature search. Use this skill for virology tasks involving get virus dataset report get virus annotation report get taxonomy search literature. Combines 4 tools from 2 SCP server(s).

Lead Compound Optimization - Optimize a lead compound: validate SMILES, compute drug-likeness, predict ADMET properties, and check ChEMBL bioactivity. Use this skill for medicinal chemistry tasks involving is valid smiles calculate mol drug chemistry pred molecule admet search activity. Combines 4 tools from 3 SCP server(s).

Calculate material density and volume from mass and geometric dimensions for materials mechanics analysis.

Analyze measurement errors, uncertainties, and statistical variations in experimental data for quality control.

Computational Analysis via Code Execution - Execute custom computational analysis code, analyze software, and search for reference implementations. Use this skill for computational science tasks involving exec code software analysis search dataset search literature. Combines 4 tools from 2 SCP server(s).

Calculate optical frequency and wavelength relationships for photonics and electromagnetic analysis.

Population Genetics Analysis - Analyze population genetics: Ensembl variation populations, linkage disequilibrium, and variant frequency data. Use this skill for population genetics tasks involving get info variation populations get ld get variation get variant recoder. Combines 4 tools from 1 SCP server(s).

Mutation Impact Analysis - Analyze mutation impact: predict structure, predict mutations from sequence and structure, and check variant effects with Ensembl VEP. Use this skill for molecular biology tasks involving pred protein structure esmfold zero shot sequence prediction predict zero shot structure get vep hgvs. Combines 4 tools from 3 SCP server(s).

Chromosome Structure Analysis - Analyze chromosome: NCBI summary, UCSC cytoband, genome sequence, and Ensembl assembly info. Use this skill for cytogenetics tasks involving get chromosome summary get cytoband get chromosome sequence get info assembly. Combines 4 tools from 3 SCP server(s).

Signal Processing Analysis - Analyze signals: duty cycle, frequency range, electron wavelength, and measurement error analysis. Use this skill for signal processing tasks involving calculate duty cycle calculate frequency range electron wavelength calculate absolute error. Combines 4 tools from 3 SCP server(s).

Polypharmacology Analysis - Analyze a drug's multi-target pharmacology: get targets from ChEMBL, functional enrichment from STRING, and pathway links from KEGG. Use this skill for pharmacology tasks involving get target by name get functional enrichment kegg link get mechanism by id. Combines 4 tools from 3 SCP server(s).

Natural Product Analysis - Analyze natural products: name to SMILES, PubChem lookup, structural analysis, and KEGG natural product search. Use this skill for natural products chemistry tasks involving NameToSMILES search pubchem by name ChemicalStructureAnalyzer kegg find. Combines 4 tools from 4 SCP server(s).

Molecular Docking Pipeline - Complete docking workflow: retrieve protein structure, predict binding pockets, prepare receptor, and dock ligand. Use this skill for structural biology tasks involving retrieve protein data by pdbcode run fpocket convert pdb to pdbqt dock quick molecule docking. Combines 4 tools from 2 SCP server(s).

Calculate buoyancy forces and acceleration for fluid mechanics and hydrodynamics analysis.

Calculate different types of molecular properties based on SMILES strings, covering basic physicochemical properties, hydrophobicity, hydrogen bonding capability, molecular complexity, topological structures, charge distribution, and custom complexity metrics, respectively.

Binding Site Characterization - Characterize binding sites: predict pockets with fpocket and P2Rank, get binding site info from ChEMBL, and visualize. Use this skill for structural biology tasks involving run fpocket pred pocket prank get binding site by id visualize protein. Combines 4 tools from 3 SCP server(s).

Given a protein sequence and its structure, employ ProSST model to predict mutation effects and obtain the top-k mutated sequences.

Protein Cross-Database Reference - Cross-reference protein: UniProt entry, NCBI gene, Ensembl xrefs, and PDB structure search. Use this skill for proteomics tasks involving get uniprotkb entry by accession get gene metadata by gene name get xrefs symbol retrieve protein data by pdbcode. Combines 4 tools from 4 SCP server(s).

Come up with good ideas about what to fix. Use when you have to fix something, but you're not sure what.

Convert triaged autoclaude GitHub issues into FIXMEs in the codebase. Use when you want to process issues that have been triaged by authorized users.

Resolve an agent name or description to an exact mngr agent name. Used by other skills that target agents.

Create 1-3 short asciinema demo recordings (5-20 seconds each) that demonstrate completed work. Use only when explicitly instructed to create demos.

全面的电子表格创建、编辑和分析，支持公式、格式、数据分析和可视化。当 Claude 需要处理电子表格（.xlsx、.xlsm、.csv、.tsv 等）时：(1) 创建带有公式和格式的新电子表格，(2) 读取或分析数据，(3) 在保留公式的同时修改现有电子表格，(4) 在电子表格中进行数据分析和可视化，或 (5) 重新计算公式

Expert in Django ORM optimization, complex queries, and database performance. Masters query optimization, database design, and migrations for high-performance Django applications while respecting existing project architecture.

Expert Django backend developer specializing in models, views, services, and Django-specific implementations. MUST BE USED for Django backend development tasks. Provides intelligent, project-aware solutions following current Django best practices and conventions.

审查代码漏洞，实施安全认证，并确保符合OWASP标准。处理JWT、OAuth2、CORS、CSP和加密。主动用于安全审查、认证流程或漏洞修复。

提供运营分析、财务跟踪、基础设施维护和客户支持能力。当需要处理运营任务、生成报告或维护系统时使用。

分析指标、创建报告并追踪 KPI。构建仪表盘、营收模型和增长预测。在需要业务指标或投资者更新时应主动使用此代理